REDOXS和METAPLUS研究结果：重症患者补充谷氨酰胺和抗氧化剂时代终结？

JPEN J Parenter Enteral Nutr. 2015 Nov;39(8):890-2.

Consequences of the REDOXS and METAPLUS Trials: The End of an Era of Glutamine and Antioxidant Supplementation for Critically Ill Patients?

van Zanten AR, Hofman Z, Heyland DK.

Department of Intensive Care, Gelderse Vallei Hospital, Ede, the Netherlands.

Nutricia Advanced Medical Nutrition, Nutricia Research, Utrecht, the Netherlands.

Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada.

Recently, 2 large-scale, multicenter randomized trials studying the effect of supplemental glutamine and antioxidants in critically ill ventilated patients have been published. Together, the results of these 2 studies challenge current guidelines and recommendations for these special nutrients.

KEYWORDS: amino acids; critical care; enteral nutrition; immunonutrition; nutrition; parenteral nutrition; research and diseases

PMID: 25567781

DOI: 10.1177/0148607114567201