Gut：肠道菌群的长期不稳定性与代谢疾病关系密切 | 热心肠日报

肠道微生物组的长期不稳定性与代谢性肝病、低菌群多样性、糖尿病和受损的胰外分泌功能相关

10.1136/gutjnl-2020-322753

11-09, Article

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Objective: The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest diseases that determine the long-term stability or instability of the microbiome are largely unknown. We aimed to identify disease-relevant phenotypes associated with faecal microbiota (in-)stability.
Design: A total of 2564 paired faecal samples from 1282 participants of the population-based Study of Health in Pomerania (SHIP) were collected at a 5-year (median) interval and microbiota profiles determined by 16S rRNA gene sequencing. The changes in faecal microbiota over time were associated with highly standardised and comprehensive phenotypic data to determine factors related to microbiota (in-)stability.
Results: The overall microbiome landscape remained remarkably stable over time. The greatest microbiome instability was associated with factors contributing to metabolic syndrome such as fatty liver disease and diabetes mellitus. These, in turn, were associated with an increase in facultative pathogens such as Enterobacteriaceae or Escherichia/Shigella. Greatest stability of the microbiome was determined by higher initial alpha diversity, female sex, high household income and preserved exocrine pancreatic function. Participants who newly developed fatty liver disease or diabetes during the 5-year follow-up already displayed significant microbiota changes at study entry when the diseases were absent.
Conclusion: This study identifies distinct components of metabolic liver disease to be associated with instability of the intestinal microbiome, increased abundance of facultative pathogens and thus greater susceptibility toward dysbiosis-associated diseases.

First Authors:
Fabian Frost

Correspondence Authors:
Markus M Lerch

All Authors:
Fabian Frost,Tim Kacprowski,Malte Rühlemann,Maik Pietzner,Corinna Bang,Andre Franke,Matthias Nauck,Uwe Völker,Henry Völzke,Marcus Dörr,Jan Baumbach,Matthias Sendler,Christian Schulz,Julia Mayerle,Frank U Weiss,Georg Homuth,Markus M Lerch