粪菌移植或调节适应性免疫治疗复发性艰难梭菌感染 | 热心肠日报
粪菌移植可增强对TcdB的适应性免疫，治疗复发性艰难梭菌感染
10.1053/j.gastro.2021.01.009
01-10, Article
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Clostridioides difficile infection (CDI) is the leading cause of gastroenteritis-associated death in North America . First line treatment is typically vancomycin, which kills vegetative forms and eliminates production of the two pathogenic toxins: TcdA and TcdB . However, 25-35% of patients experience recurrent disease . Fecal microbiota transplant (FMT) is an effective secondline therapy for recurrent CDI , but remains difficult to access, carries infectious risk if not done carefully, and multiple treatments may be needed.
First Authors:
Laura Cook
Correspondence Authors:
Megan K Levings,Theodore S Steiner
All Authors:
Laura Cook,William D Rees,May Q Wong,Hannah Peters,Megan K Levings,Theodore S Steiner