T1型造影剂介绍及MRI产品介绍-齐岳生物
T1型造影剂介绍及MRI产品介绍-齐岳生物
核磁共振成像MRI造影剂可以分为纵向弛豫造影剂 (T1制剂)和横向弛豫造影剂（T2制剂）。T1制剂是通过水分子中的氢核和顺磁性金属离子直接作用来缩短T1，从而增强信号，图像较亮；T2制剂是通过对外部局部磁性环境的不均匀性进行干扰，使邻近氢质子在弛豫中很快产生相(diphase)来缩短T2，从而减弱信号，图像较暗。
弛豫效率是MRI造影剂关键指标之一。弛豫效率高的样品，可以使用少的量达到好的效果；在造影剂研究领域，纽迈专门开发了小型的核磁共振成像分析仪，可测试方便的测试造影剂T1、T2弛豫时间，并可对试管样品进行成像，提供定量和定性评价数据，为造影剂产品的研发与改进提供快速可靠的检测手段。
目前市面上的T1造影剂产品是Gd钆及Gd的衍生物产品，常用的就是Gd-DTPA钆喷替酸葡甲胺。
Magnetic resonance imaging (MRI) is an imaging technique usedprimarily in medical research to produce high quality images of in vivosystems. To track materials within in vivo systems, compounds-of-interest aretagged with materials that possess magnetic properties. These materials, aswell as MRI contrast agents, generally fall into two classes. The first issoluble gadolinium compounds that act through the T1 relaxation process and arebrightening agents. The second is particulate iron oxides that act through theT2 relaxation process and are darkening agents. Each type of contrast agent hasits benefits.
T1造影剂的产品列表如下：
Gd-DTPA
Gadolinium-Labeled Albumin
Gadolinium-labeled IgG
Gadolinium-labeled Protein A
Gadolinium-labeled Polylysine
Gadolinium-labeled BSA
Gd-BSA-FITC
Gd-BSA-Rhodamine B
Gd-DOTA
Gd-p-SCN-Bn-DOTA
Gd-DO3A-Butylamine
DMPE-DTPA-Gd
DTPA-BSA-Gd
DPPE-DTPA-Gd
DSPE-DTPA-Gd
DMPE-DTPA-Gd-DMPE
DPPE-DTPA-Gd-DPPE
DSPE-DTPA-Gd-DSPE
产品名称：Gd-DTPA/Gado-DTPA
产品全称：Gadolinium-DTPA
中文名称：2乙3胺5乙酸钆络合物/钆喷酸葡甲胺盐
外观：液体
Formula : C28H54GdN5O20
溶剂：0.5 mmol gadopentetatedimeglumine/ml
浓度：469 mg/ml
包装：10ml
保存时间：4℃，2年
产品名称：Gd-BSA
产品全称：Gadolinium-labeledbovine albumin
中文名称：钆-牛血清白蛋白
产品简介：
One ml of Galbumin, Trackable Galbumin, orGlowing Galbumin is packaged in a 2 ml sealed serum bottles at a concentrationof 25 mg/ml. Concentrated Galbumin is packaged in a 2 ml sealed serum bottlesat 100 mg/ml. Applications include vascular imaging and injection andinjection-site visualization. Suggested starting dose for rats and mice is 2-4ml/kg.
分子量：66K
外观：液体
浓度：25 mg/ml
包装：2ml
保存时间：4℃，2年
产品名称：Gd-BSA-FITC
产品全称：Gadolinium-labeledbovine albumin-Fluorescein
中文名称：钆-牛血清白蛋白-绿色荧光素
外观：液体
激发和发射：490nm-520nm
浓度：25 mg/ml
包装：2ml
保存时间：4℃，2年
用于荧光成像
产品名称：Gd-BSA-RhodamineB
产品全称：Gadolinium-labeledbovine albumin-Rhodamine B
中文名称：钆-牛血清白蛋白-红色罗丹明
外观：液体
激发和发射：570nm-610nm
浓度：25 mg/ml
包装：2ml
保存时间：4℃，2年
用于荧光成像
产品名称：Gd-IgG
产品全称：Gadolinium-labeled Immunoglobulin G(bovine), Gd-IgG
中文名称：钆-抗体
介绍：
Gd-IgG is gadolinium-labeled IgG. Thisreagent is engineered to be used as a MRI contrast reagent and is classified asa brightening agent acting through the T1 relaxation process. Gd-IgG is at aconcentration of 25 mg/ml. There are approximately 10 to 15 gadolinium atomsper IgG unit and the molecular weight of the product is approximately 160 kDa.
外观：液体
浓度：10 mg/ml
包装：2ml
保存时间：4℃，2年
产品名称：Gd-Protein A
产品全称：Gd-ProteinA, Gadolinium-Protein A
中文名称：钆-蛋白A
介绍：
Gado-Protein A is gadolinium-labeledProtein A bottled at a concentration of 10 mg/ml. There are approximately 3gadolinium atoms per Protein A unit and the molecular weight of the product is~ 44k Da.
Protein A is a 42 kDa surface proteinoriginally found in the cell wall of the bacterium Staphylococcus aureus. Ithas found use in biochemical research because of its ability to bindimmunoglobulins from many mammalian species. It binds the heavy chain withinthe Fc region of most immunoglobulins and also within the Fab region in thecase of the human VH3 family.
外观：液体
浓度：25 mg/ml
包装：2ml
保存时间：4℃，2年
产品名称：Gd3O4
产品全称：Gadoliniumoxide nanoparticles
中文名称：纳米钆氧化物
介绍：
Gadoluminate is the first commerciallyavailable ultra-small gadolinium oxide colloid for use in a wide range of MRIand MRA applications. This product is a 30 nm gadolinium colloid and itprovides a strong T1 brightening signal that is comparable to the same molarconcentration as Gd-DTPA. However, due to its colloidal size and neutralcharge, this reagent is retained in the vascular space. The measured bloodhalf-life (t½) of Gadoluminate in a swine model is approximately 12.5 hours andapproximately 11.9 minutes in a mouse model.
Two ml of Gadoluminate is packaged in a 2ml sealed serum bottles. The product is a 30 nm gadolinium colloid atconcentration of 10 mg Gd/ml.
外观：液体
粒径：30纳米
浓度：15 mg/ml
包装：2ml
保存时间：4℃，2年
产品名称：PLL-Gd
产品全称：Gadolinium-Polylysine/Gadolinium-labeledpolylysine
中文名称：聚赖氨酸-钆
介绍：
Gado-Polylysine is gadolinium-labeledpolylysine. This reagent is engineered to be used as a MRI contrast reagent andis classified as a brightening agent acting through the T1 relaxationprocess. GADOPOLYLYSINE is designed for diffusion studies, for labelingcells, and to allow efficient labeling with ligands, peptides, proteins, andnucleic acid (RNAi, DNA, etc.), wherein a T1 weighted MRI contrast agent isdesired.
外观：液体
分子量：10k, 22k,50k,110k, 225k
浓度：10 mg/ml
包装：2ml
保存时间：4℃，2年
产品名称：Gd-DOTA
产品全称：Gadolinium-Gadolinium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
中文名称： 钆-大环配体
外观：粉末
Formula: Gd C₁₆H₂₄N₄O₈Na·4H₂O
FW: 652.7
包装：500mg/1g
保存时间：-20℃，1年
Gd-p-SCN-Bn-DOTA
产品名称：Gd-p-SCN-Bn-DOTA
中文名称： 钆-大环配体
外观：粉末
Formula: GdC₂₄H₃₀N₅O₈·TFA
FW: 819.9.
纯度：94%
包装：500mg/1g
保存时间：-20℃，1年
产品名称：14:0PE-DTPA (Gd)，DMPE-DTPA-Gd
产品全称：1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaaceticacid (gadolinium salt)
中文名称： 钆-大环配体-磷脂
外观：粉末
Molecular Formula：C47H90GdN6O17P
Percent Composition：C 47.06%, H 7.56%, Gd 13.11%, N 7.01%, O 22.68%, P 2.58%
Purity：>99%
CAS Number：827020-81-5
Molecular Weight：1199.471
纯度：99%
包装：5mg/10mg
保存时间：-20℃，1年
产品名称：DTPA-BSA(Gd)，DTPA-BSA-Gadolinium
产品全称：DTPA-bis(stearylamide)(gadolinium salt)
中文名称： 钆-大环配体-牛血清白蛋白
外观：粉末
Molecular Formula：C50H94GdN5O8
Percent Composition：C 57.16%, H 9.02%, Gd 14.97%, N 6.67%, O 12.18%
Purity：>99%
CAS Number：186796-30-5
Molecular Weight：1050.560
纯度：99%
包装：5mg/10mg
保存时间：-20℃，1年