地氟醚和七氟醚对腹腔镜胆囊切除术患者Nesfatin-1水平的影响：随机对照试验
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The effects of Desflurane and Sevoflurane on Nesfatin-1 levels in laparoscopic Cholecystectomy: a randomized controlled trial
背景与目的
Nesfatin-1参与心血管调节及与压力相关的反应。本研究的目的是探讨挥发性麻醉药对Nesfatin-1水平的影响。
方 法
本研究纳入了42例年龄在30-65岁之间、ASA分级I-II级的择期腹腔镜胆囊切除术患者。随机将其分为两组：地氟烷给药组（组I，n = 21）和七氟醚给药组（组II，n = 21）。患者在吸入40％O2和60％空气混合气体的同时给予6％地氟醚或2％七氟醚用于麻醉维持。在诱导前，诱导后，插管后和拔管期间分别监测并记录患者的心率（HR），平均动脉压、收缩压和舒张压（MAP，SAP，DAP）及脉氧饱和度（SpO2）。在诱导前（T1）和拔管后且aldrete评分为10（T2）时，收集血液样本。
结 果
两组的人口统计数据差异无统计学意义。两组术前的nesfatin水平相似（p = 0.715）。 地氟醚组术后的nesfatin水平与术前水平相似（p = 0.073）。 七氟醚组术后的nesfatin水平与术前相似（p = 0.131）。两组的nesfatin水平（术后vs术前）差异无统计学意义（p = 0.900）。
结 论
综上所述，本研究结果表明七氟醚或地氟醚不影响腹腔镜胆囊切除术患者的nesfatin-1水平。
原始文献摘要
Ozcan ATD, Altin CB, Erdogan S, Ergin M, Çiftçi A, Kara H, Aksoy SM, But A；The effects of Desflurane and Sevoflurane on Nesfatin-1 levels in laparoscopic Cholecystectomy: a randomized controlled trial；
BMC Anesthesiol. 2018 Feb 16;18(1):23. doi: 10.1186/s12871-018-0484-x.
Background: Nesfatin-1 is involved in cardiovascular regulation, stress-related responses. The objective of this study is to investigate the impact of volatile anesthetics on Nesfatin-1 levels.
Method: Fourty-two patients aged 30–65 years with the American Society Anesthesiology (ASA) Class I-II who were scheduled for laparoscopic cholecystectomy were included in the study Patients were randomized into two group; desflurane administered group (Group I, n = 21) and sevoflurane administered group (Group II, n = 21). For anesthesia
maintenance, the patients received 6% desflurane or 2% sevoflurane in 40% O2 and 60% air. The patient’s heart rate (HR), mean, systolic and diastolic arterial pressures (MAP, SAP, DAP), peripheral O2 saturation (SpO2) were monitored and recorded before induction, after induction, after intubation, and during extubation. Blood samples were collected
before induction (T1), and after extubation when aldrete score was 10 (T2).
Results: Demographic data were similar between the groups. The preoperative levels of nesfatin were similar in the two groups (p = 0.715). In desflurane group, post-operative nesfatin levels were similar compared to preoperative levels (p = 0.073). In sevoflurane group, post-operative nesfatin levels were similar (p = 0.131). The nesfatin levels (postoperative vs preoperative) were similar between the groups (p = 0.900).
Conclusion: In conclusion, this study results suggest that nesfatin-1 levels are not affected by the use of sevoflurane or desflurane in patients undergoing laparoscopic cholecystectomy.
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