Sorafenib-索拉菲尼

{"root":{"nodeName":"document","nodeValue":null,"nodeType":"0","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"table","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"tbody","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"药物名称","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;border-left: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"sorafenib","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"化学结构","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-bottom: 16px;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]},{"nodeName":"img","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"},{"attrName":"src","attrValue":"//image109.360doc.com/DownloadImg/2021/03/1812/217942438_1_20210318122039911_wm"}],"childNodes":[]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"商品名称","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"Nexavar","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":" 多吉美","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"适应症","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"治疗不能手术的晚期肾细胞癌；治疗无法手术或远处转移的原发肝细胞癌。","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"给药途径","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"口服","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"靶点","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"多种激酶抑制剂（CRAF、BRAF、V600EBRAF、c-Kit、FLT-3）","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"药物特点","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"索拉非尼是多种激酶抑制剂，体外试验显示它可抑制肿瘤细胞增殖和抗血管生成作用。索拉非尼抑制肿瘤细胞的靶部位CRAF、BRAF、V600EBRAF、c-Kit、FLT-3和肿瘤血管靶部位的CRAF、VEGFR-2、VEGFR-3、PDGFR-β。RAF激酶是丝氨酸/苏氨酸激酶，而c-Kit、FLT-3、VEGFR-2、VEGFR-3、PDGFR-β为络氨酸激酶，这些激酶作用于肿瘤细胞信号通路、血管生成和凋亡。 体内试验显示，在多种人肿瘤抑制裸鼠模型中，如人肝细胞肿瘤、肾细胞肿瘤中，可抑制肿瘤生长和血管生成。","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"原研公司","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"Bayer AG","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"研发历史","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"待更新","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"上市时间","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"2005","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"国内上市时间","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"2010","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"国内申报厂家","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"江苏豪森药业股份有限公司、四川科伦药业股份有限公司、石药集团中奇制药技术（石家庄）有限公司、正大天晴药业集团股份有限公司、杭州中美华东制药有限公司、江苏嘉逸医药有限公司、重庆药友制药有限责任公司 etc","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"原研专利","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"信息","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"专利号","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"到期日","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"专利名称","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"WO-03068746","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"2023","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"Aryl ureas as kinase inhibitors","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"全球销售","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"预测","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"img","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"},{"attrName":"src","attrValue":"//image109.360doc.com/DownloadImg/2021/03/1812/217942438_2_20210318122040192_wm"}],"childNodes":[]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":" color: rgb(62, 62, 62); white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box; overflow-wrap: break-word;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"background-color: rgb(214, 214, 214);;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"background-color: rgb(214, 214, 214);box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":"S ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]},{"nodeName":"br","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[],"childNodes":[]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":" color: rgb(62, 62, 62); white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box; overflow-wrap: break-word;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"text-align: center;box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"text-align: center;background-color: rgb(214, 214, 214);box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":"W","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":" color: rgb(62, 62, 62); white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box; overflow-wrap: break-word;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"text-align: center;box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"text-align: center;background-color: rgb(214, 214, 214);box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":"O","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":" color: rgb(62, 62, 62); white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box; overflow-wrap: break-word;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"text-align: center;box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"background-color: rgb(214, 214, 214);box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" T","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box ;word-wrap: break-word ;;"}],"childNodes":[{"nodeName":"text","nodeValue":" ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"1. FDA批准的首个肝癌治疗药物","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"2. 口服给药，服用方便","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"3. 专利保护到2020年","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"1. 不耐受，疲劳，手足综合征，腹泻和高血压副作用常见","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"2. 一天两次，且不能与食物同时服用","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"3. 非小细胞肺癌临床试验不成功","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"1. 肾癌、肝癌全球市场容量较大","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"2. 不可手术的肝癌患者适用药物较少","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"3. 亚洲肝癌人数较多，市场潜力大","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"1. 专利即将过期，仿制药潜在竞争力","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"2. PD-1抑制剂Opdivo显示出较好的临床效果","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"3. 手术治疗仍然成为肝癌的主要治疗方式 ","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;word-break: break-all;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"原研工艺路线","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"待更新","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"tr","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;border-top: none;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"杂质信息","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"td","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: none;border-left: none;border-bottom-color: windowtext;border-right-color: windowtext;word-break: break-all;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"待更新","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"white-space: normal;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"box-sizing: border-box;border-style: none;border-color: initial;word-wrap: break-word !important;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin: 2px auto;box-sizing: border-box;border-style: initial;border-color: initial;word-wrap: break-word !important;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin:0px 4px;padding: 0.8em;box-sizing: border-box;border-style: solid;border-color: rgb(117, 117, 118);box-shadow: rgb(117, 117, 117) 0px 0px 4px;color: inherit;word-wrap: break-word !important;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"word-wrap: break-word;color: rgb(51, 51, 51);line-height: 1.4;word-break: break-all;box-sizing: border-box !important;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"text-align: center;;"}],"childNodes":[{"nodeName":"strong","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"color: rgb(255, 76, 65);;"}],"childNodes":[{"nodeName":"text","nodeValue":"Sorafenib","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"color: rgb(255, 76, 65);;"}],"childNodes":[{"nodeName":"strong","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"汤","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"color: rgb(255, 76, 65);;"}],"childNodes":[{"nodeName":"strong","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"森","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[]},{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[]},{"nodeName":"strong","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"路透","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]},{"nodeName":"strong","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"Cortellis","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"strong","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"报告免费下载","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"text-align: center;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":";"}],"childNodes":[{"nodeName":"text","nodeValue":"https://pan.baidu.com/s/1aCOz27VpwnoHVvLIt2zNnA","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]}]}]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"white-space: normal;text-align: center;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-style: none;border-color: initial;box-sizing: border-box;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-right: auto;margin-left: auto;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"vertical-align: top;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"vertical-align: top;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-top: 0.5em;margin-bottom: 0.5em;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: 1px dotted rgb(223, 223, 223);box-sizing: border-box;;"}],"childNodes":[]}]}]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"vertical-align: top;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-top: 5px;margin-bottom: 10px;line-height: 0.8;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: 0.8em solid rgb(187, 227, 197);box-sizing: border-box;border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;;"}],"childNodes":[]}]}]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"vertical-align: top;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-top: 0.5em;margin-bottom: 0.5em;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: 1px dotted rgb(223, 223, 223);box-sizing: border-box;;"}],"childNodes":[]}]}]}]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"padding-right: 10px;padding-left: 10px;text-align: justify;letter-spacing: 0px;line-height: 2;color: rgb(160, 160, 160);box-sizing: border-box;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"text-indent: 0em; text-align: center;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"color: rgb(136, 136, 136);;"}],"childNodes":[{"nodeName":"text","nodeValue":"学如逆水行舟，不进则退；","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"text-indent: 0em; text-align: center;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"color: rgb(136, 136, 136);;"}],"childNodes":[{"nodeName":"text","nodeValue":"心似平原走马，易放难收。","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"vertical-align: top;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-top: 18px;margin-bottom: 8px;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: 1px dotted rgb(223, 223, 223);box-sizing: border-box;;"}],"childNodes":[]}]}]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"vertical-align: top;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-top: 10px;margin-bottom: 10px;line-height: 0.8;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-bottom: 0.8em solid rgb(121, 204, 213);box-sizing: border-box;border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;;"}],"childNodes":[]}]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"vertical-align: top;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-top: 18px;margin-bottom: 8px;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-top: 1px dotted rgb(223, 223, 223);box-sizing: border-box;;"}],"childNodes":[{"nodeName":"br","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]}]}]}]}]}]}]}]},{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"white-space: normal; text-align: center;;"}],"childNodes":[{"nodeName":"img","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"display: inline;;"},{"attrName":"src","attrValue":"//image109.360doc.com/DownloadImg/2021/03/1812/217942438_3_20210318122040583"}],"childNodes":[]}]},{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"white-space: normal;text-align: center;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"border-style: none;border-color: initial;box-sizing: border-box;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-right: auto;margin-left: auto;padding: 0.5em 0em;overflow: hidden;border-radius: 5px;border-style: solid;border-color: rgb(200, 200, 200);box-sizing: border-box !important;word-wrap: break-word !important;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"margin-bottom: 0.5em;overflow: hidden;vertical-align: bottom;box-sizing: border-box !important;word-wrap: break-word !important;;"}],"childNodes":[{"nodeName":"section","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":"vertical-align: top;box-sizing: border-box !important;word-wrap: break-word !important;;"}],"childNodes":[{"nodeName":"p","nodeValue":null,"nodeType":"1","display":"block","nodeAttrs":[{"attrName":"style","attrValue":" box-sizing: border-box; overflow-wrap: break-word;;"}],"childNodes":[{"nodeName":"span","nodeValue":null,"nodeType":"1","display":"inline","nodeAttrs":[{"attrName":"style","attrValue":"color: rgb(136, 136, 136);;"}],"childNodes":[{"nodeName":"text","nodeValue":"行舟Drug","nodeType":"3","display":"inline","nodeAttrs":[],"childNodes":[]}]}]}]}]}]}]}]}]},"imageUrls":["https://image109.360doc.com/DownloadImg/2021/03/1812/217942438_1_20210318122039911_wm","https://image109.360doc.com/DownloadImg/2021/03/1812/217942438_2_20210318122040192_wm","https://image109.360doc.com/DownloadImg/2021/03/1812/217942438_3_20210318122040583"],"text":"药物名称sorafenib化学结构 商品名称Nexavar 多吉美适应症治疗不能手术的晚期肾细胞癌；治疗无法手术或远处转移的原发肝细胞癌。给药途径口服靶点多种激酶抑制剂（CRAF、BRAF、V600EBRAF、c-Kit、FLT-3）药物特点索拉非尼是多种激酶抑制剂，体外试验显示它可抑制肿瘤细胞增殖和抗血管生成作用。索拉非尼抑制肿瘤细胞的靶部位CRAF、BRAF、V600EBRAF、c-Kit、FLT-3和肿瘤血管靶部位的CRAF、VEGFR-2、VEGFR-3、PDGFR-β。RAF激酶是丝氨酸/苏氨酸激酶，而c-Kit、FLT-3、VEGFR-2、VEGFR-3、PDGFR-β为络氨酸激酶，这些激酶作用于肿瘤细胞信号通路、血管生成和凋亡。 体内试验显示，在多种人肿瘤抑制裸鼠模型中，如人肝细胞肿瘤、肾细胞肿瘤中，可抑制肿瘤生长和血管生成。原研公司Bayer AG研发历史待更新上市时间2005国内上市时间2010国内申报厂家江苏豪森药业股份有限公司、四川科伦药业股份有限公司、石药集团中奇制药技术（石家庄）有限公司、正大天晴药业集团股份有限公司、杭州中美华东制药有限公司、江苏嘉逸医药有限公司、重庆药友制药有限责任公司 etc原研专利信息专利号到期日专利名称WO-030687462023Aryl ureas as kinase inhibitors全球销售预测  S   W   O   T 1. FDA批准的首个肝癌治疗药物2. 口服给药，服用方便3. 专利保护到2020年1. 不耐受，疲劳，手足综合征，腹泻和高血压副作用常见2. 一天两次，且不能与食物同时服用3. 非小细胞肺癌临床试验不成功1. 肾癌、肝癌全球市场容量较大2. 不可手术的肝癌患者适用药物较少3. 亚洲肝癌人数较多，市场潜力大1. 专利即将过期，仿制药潜在竞争力2. PD-1抑制剂Opdivo显示出较好的临床效果3. 手术治疗仍然成为肝癌的主要治疗方式 原研工艺路线待更新杂质信息待更新Sorafenib汤森路透Cortellis报告免费下载https://pan.baidu.com/s/1aCOz27VpwnoHVvLIt2zNnA学如逆水行舟，不进则退；心似平原走马，易放难收。行舟Drug"}