感恩并传承丨广东省人民医院吴一龙教授团队-中国肺癌原创临床研究阶段汇总

读书笔记丨感恩并传承CTONG-中国肺癌原创临床研究

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Lancet Oncol

Lancet Oncol Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study  Yi-long Wu (2011)

Lung Cancer

Lung Cancer  Efficacy and safety of maintenance erlotinib in Asian patients with advanced non-small-cell lung cancer: A subanalysis of the phase III, randomized SATURN study  Yi-long Wu (2012)

Chin J Cancer Res

Chin J Cancer Res  Nedaplatin/Gemcitabine versus Carboplatin/Gemcitabine in treatment of advanced non-small cell lung cancer: A randomized clinical trial  Yi-long Wu (2012)

Ann Oncol

Ann Oncol  Erlotinib as second-line treatment in patients with advanced non-small-cell lung cancer and a symptomatic brain metastases: a phase II study (CTONG-0803) Yi-long Wu (2013)

Lancet Oncol

Lancet Oncol  Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial  Yi-long Wu (2013)

Lung Cancer

Lung Cancer  A multicenter phase II study of sorafenib monotherapy in clinically selected patients with advanced lung adenocarcinoma after failure of EGFR-TKI therapy (Chinese Thoracic Oncology Group, CTONG 0805)  Yi-long Wu (2013)

Lancet Oncol

Lancet Oncol  Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial Yi-long Wu (2014)

Lung Cancer

Lung Cancer Efficacy and safety of pemetrexed/cisplatin versus gemcitabine/cisplatin as first-line treatment in Chinese patients with advanced nonsquamous non-small cell lung cancer  Yi-long Wu (2014)

Ann Oncol

Ann Oncol Pemetrexed versus gefitinib as a second-line treatment in advanced nonsquamous nonsmall-cell lung cancer patients harboring wild-type EGFR (CTONG0806): a multicenter randomized trial  Yi-long Wu (2014)

Lancet Oncol

Lancet Oncol Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials  Yi-long Wu  (2014)

J Hematol Oncol

J Hematol Oncol  Phase II study of biomarker-guided neoadjuvant treatment strategy for IIIA-N2 non-small cell lung cancer based on epidermal growth factor receptor mutation status  Yi-long Wu (2015)

Ann Oncol

Ann Oncol Final overall survival results from a randomised, Phase III study of erlotinib versus chemotherapy as first-line treatment of EGFR mutation-positive advanced non-small-cell lung cancer (OPTIMAL, CTONG-0802) Yi-long Wu (2015)

Ann Oncol

Ann Oncol First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study  Yi-long Wu (2015)

J Hematol Oncol

J Hematol Oncol  Serial cfDNA assessment of response and resistance to EGFR-TKI for patients with EGFR-L858R mutant lung cancer from a prospective clinical trial  Yi-long Wu (2016)

Lung Cancer

Lung Cancer Tumor marker analyses from the phase III, placebo-controlled, FASTACT-2 study of intercalated erlotinib with gemcitabine/platinumin the first-line treatment of advanced non-small-cell lung cancer  Yi-long Wu (2016)

Lancet Respir Med

Lancet Respir Med  Icotinib versus whole-brain irradiation in patients with EGFR-mutant non-small-cell lung cancer and multiple brain metastases (BRAIN): a multicentre, phase 3, open-label, parallel, randomised controlled trial Yi-long Wu (2016)

Br J Cancer

Br J Cancer  A phase III randomised controlled trial of erlotinib vs gefitinib in advanced non-small cell lung cancer with EGFR mutations  Yi-long Wu (2016)

Lancet Oncol

Lancet Oncol  Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial Yi-long Wu (2016)

Br J Cancer

Br J Cancer EGFR mutation detection in circulating cell-free DNA of lung adenocarcinoma patients: analysis of LUX-Lung 3 and 6  Yi-long Wu (2016)

Lung Cancer

Lung Cancer Efficacy according to blind independent central review: post-hoc analyses from the Phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC Yi-long Wu (2017)

N Engl J Med

N Engl J Med  Osimertinib or platinum-pemetrexedin EGFR T790M-positive lung cancer  Yi-long Wu (2017)

Lancet Respir Med

Lancet Respir Med  Detection of EGFR mutations in plasma circulating tumor DNA as a selection criterion for first-line gefitinib treatment in patients with advanced lung adenocarcinoma (BENEFIT): a phase 2, single-arm, multicentre clinical trial  Yi-long Wu (2018)

J Clin Oncol

J Clin Oncol Improvement in overall survival in a randomized study that compared Dacomitinib with Gefitinib in patients with advanced non-small-cell lung cancer and EGFR activating mutations Yi-long Wu (2018)

J Clin Oncol

J Clin Oncol  Phase Ib/II study of Capmatinib (INC280) plus Gefitinib after failure of Endothelial Growth Factor Receptor (EGFR) Inhibitor therapy in patients with EGFR-mutated, MET Factor-Dysregulated non-small-cell lung cancer Yi-long Wu (2018)

J Clin Oncol

J Clin Oncol Phase II study of Crizotinib in East Asian patients with ROS1-positive advanced non-small-cell lung cancer Yi-long Wu (2018)

J Thorac Oncol

J Thorac Oncol  Results of PROFILE 1029, a phase III comparison of first-line Crizotinib versus chemotherapy in East Asian patients with ALK-positive advanced non-small cell lung cancer  Yi-long Wu (2018)

J Thorac Oncol

J Thorac Oncol  The unique spatial-temporal treatment failure patterns of adjuvant Gefitinib Therapy: A Post Hoc  analysis of the ADJUVANT Trial (CTONG 1104)  Yi-long Wu (2018)

Eur J Cancer

Eur J Cancer  A randomised phase II clinical trial of nab-paclitaxel and carboplatin compared with gemcitabine and carboplatin as first-line therapy in advanced squamous cell lung carcinoma (C-TONG1002)  Yi-long Wu (2018)

Lung Cancer

Lung Cancer  Clinical utility of a blood-based EGFR mutation test in patients receiving first-line erlotinib therapy in the ENSURE, FASTACT-2, and ASPIRATION studies Yi-long Wu (2018)

Lung Cancer

Lung Cancer Dynamic change of fatigue of pemetrexed maintenance treatment in the JMEN trial   Yi-long Wu (2018)

Lung Cancer

Lung Cancer  EGFR mutation analysis for prospective patient selection in AURA3 phase III trial of osimertinib versus platinum-pemetrexed in patients with EGFR T790M-positive advanced non-small-cell lung cancer  Yi-long Wu (2018)

Patient

Patient Does EGFR mutation type influence patient-reported outcomes in patients with advanced EGFR mutation-positive non-small-cell lung cancer? Analysis of two large, phase III studies comparing Afatinib with chemotherapy (LUX-Lung 3 and LUX-Lung 6)  Yi-long Wu (2018)

Onco Targets Ther

Onco Targets Ther Afatinib versus gemcitabine/cisplatin for first-line treatment of Chinese patients with advanced non-small-cell lung cancer harboring EGFR mutations: subgroup analysis of the LUX-Lung 6 trial  Yi-long Wu (2018)

EBioMedicine

EBioMedicine  Analysis of resistance mechanisms to abivertinib, a third-generation EGFR tyrosinekinase inhibitor, in patients with EGFR T790M-positive non-small cell lung cancer from a phase I trial Yi-long Wu (2019)

Am J Clin Oncol

Am J Clin Oncol  Efficacy and safety of Gefitinib as third-line treatment in NSCLC patients with activating EGFR mutations treated with First-line Gefitinib followed by second-line chemotherapy A single-arm, prospective, multicenter phase II study (RE-CHALLENGE, CTONG1304)   Yi-long Wu (2019)

J Clin Oncol

J Clin Oncol Erlotinib versus Gemcitabine plus Cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-celllung cancer (EMERGING-CTONG 1103): A randomized phase II study Yi-long Wu (2019)

J Thorac Oncol

J Thorac Oncol  Nivolumab versus Docetaxel in a predominantly Chinese patient population with previously treated advanced NSCLC: CheckMate 078 randomized phase III clinical trial  Yi-long Wu (2019)

Lung Cancer

Lung Cancer Erlotinib versus gemcitabine/cisplatin in Chinese patients with EGFR mutation-positive advanced non-small-cell lung cancer: Crossover extension and post-hoc analysis of the ENSURE study Yi-long Wu (2019)

Lung Cancer

Lung Cancer Phase 1/2 study of ceritinib in Chinese patients with advanced anaplastic lymphoma kinase-rearranged non-small cell lung cancer previously treated with crizotinib:Results from ASCEND-6  Yi-long Wu (2020)

N Engl J Med

N Engl J Med  Osimertinib in resected EGFR-mutated non-small-cell lung cancer   Yi-long Wu (2020)

Lancet Respir Med

Lancet Respir Med  Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous EGFR inhibitor (INSIGHT study): an open-label, phase 1b/2, multicentre, randomised trial  Yi-long Wu (2020)

J Clin Oncol

J Clin Oncol  Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stage II-IIIA (N1-N2) EGFR-mutat NSCLC: Final overall survival analysis of CTONG1104 phase III trial Yi-long Wu (2020)

Ann Oncol

Ann Oncol Comparing nanoparticle polymeric micellar paclitaxel and solvent-based paclitaxel as first-line treatment of advanced non-small cell lung cancer:an open-label,randomized,multicenter,phase III trial Yi-long Wu (2020)

Lung Cancer

Lung Cancer Nivolumab versus docetaxel in a predominantly Chinese patient population with previously treated advanced non-small cell lung cancer: 2-year follow-up from a randomized, open-label, phase 3 study (CheckMate 078) Yi-long Wu (2020)

Invest New Drugs

Invest New Drugs A phase Ib study of the highly selective MET-TKI savolitinib plus gefitinib in patients with EGFR-mutated, MET-amplified advanced non-small-cell lung cancer Yi-long Wu (2020)

Int J Cancer

Int J Cancer Randomized clinical trial of pembrolizumab vs chemotherapy for previously untreated Chinese patients with PD-L1-positive locally advanced or metastatic non-small-cell lung cancer: KEYNOTE-042 China study  Yi-long Wu (2021)

Drugs

Drugs Updated overall survival in a randomized study comparing Dacomitinib with Gefitinib as first-line treatment in patients with advanced non-small-cell lung cancer and EGFR-activating mutations  Yi-long Wu (2021)

Clin Lung Cancer

Clin Lung Cancer Predictive and prognostic potential of TP53 in patients with advanced non-small-cell lung cancer treated with EGFR-TKI: Analysis of a phase III randomized clinical trial (CTONG 0901)  Yi-long Wu (2021)

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