布洛芬对Colles骨折后骨愈合的影响
Influence of Ibuprofen on Bone Healing After Colles' Fracture: A Randomized Controlled Clinical Trial.
Journal of Orthopaedic Research, 2020, 38(3):545-554.
布洛芬对Colles骨折后骨愈合的影响：一项随机对照临床试验（RCT）。
Ibuprofen
/ˌaɪbjuːˈproʊfen/
n. 布洛芬，异丁苯丙酸（抗炎，镇痛药）
摘要：
Non-steroidal anti-inflammatory drugs (NSAIDs) may delay bone healing. [Therefore, it is important to establish确定 whether NSAID preparations制剂 delay bone healing and what correlations, if any, exist between different bone studies-DEXA-scanning双能X线扫描（骨密度）, bone markers, roentgenology 伦琴射线学（X线）controls, and histological组织学 examination of newly formed bone]. The purpose of this prospective controlled study前瞻性对照研究 was to investigate whether ibuprofen affects bone mineral density, turnover biomarkers骨转换生物标志物, and histomorphometric组织形态计量学 characteristics of the callus骨痂 after a Colles' fracture. This study was a single-center, triple-blinded, randomized clinical trial. Ninety-five patients (80 females) with displaced Colles' fracture, median age 65 (range 40-85) years were included in the study and operated on by external fixation from June 2012 through to June 2015. Eighty-nine patients received interventional medicine and 83 completed the 1-year follow-up. The 7-day ibuprofen group received 600 mg of ibuprofen three times a day (N = 29), the 3-day ibuprofen group received ibuprofen for 3 days (N = 30) and a placebo安慰剂 for the following 4 days, and finally, the placebo group received a placebo for 7 days (N = 30). The primary outcome was the difference in bone mineral density between the ultra-distal region of the injured and non-injured radius at 3 months after surgery. The histomorphometric outcomes included the assessment of callus tissue volume and surface fractions骨痂组织体积和表面分数 at 6 weeks postoperatively. The biomarkers Osteocalcin骨钙素 and CrossLaps胶原特殊序列 were measured at baseline, 1 week, 2 weeks, 6 weeks, 3 months, and 1 year. We included the results of the dropped-out patients in the intention to treat analysis. There was no difference between treatment groups in bone mineral density, histomorphometric estimations, and changes in bone biomarkers. These findings may offer an indication of ibuprofen as a bone-safe analgesic镇痛剂 treatment in an acute fracture-phase.
placebo
/pləˈsiːboʊ/
n. 安慰剂
百度翻译：
非甾体抗炎药（NSAIDs）可能延缓骨愈合。[因此，重要的是要确定非甾体抗炎药制剂是否延缓骨愈合，以及不同的骨研究（如有）之间存在什么关系，如DEXA扫描、骨标志物、x线对照和新形成骨的组织学检查]。这项前瞻性对照研究的目的是研究布洛芬是否影响Colles骨折后骨密度、骨转换生物标志物和骨痂的组织形态计量学特征。本研究为单中心、三盲、随机临床试验。从2012年6月到2015年6月，共有95名患者（80名女性）患有移位的Colles骨折，平均年龄65岁（40-85岁）。89例接受外固定治疗，83例完成1年随访。7天布洛芬组每天三次服用600毫克布洛芬（N = 29），3天布洛芬组连续3天服用布洛芬（N = 30），随后4天服用安慰剂，最后，安慰剂组连续7天服用安慰剂（N = 30）。主要结果是术后3个月受伤和未受伤桡骨远端骨密度的差异。组织形态测量结果包括术后6周骨痂组织体积和表面分数的评估。在基线、1周、2周、6周、3个月和1年时测量骨钙素和CrossLaps的生物标记物。我们将退学患者的结果纳入意向治疗分析。在骨密度、组织形态计量学估计和骨生物标志物变化方面，治疗组之间没有差异。这些发现可能为布洛芬在急性骨折期作为一种骨安全的镇痛治疗提供了一个指征。