还没发论文？2020年医学生信分析有这些！
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一. 生信友好杂志详解
带你了解 ①Aging现在的状况如何？②Aging成了纯生信灌水的乐园？
2.即将突破5分的Frontiers in Oncology是灌水杂志吗？
带你了解 ①Front Oncol发表的生信文章的文章类型为哪几类？②纯生信文章的发表周期如何？
3.马上4分年刊近2000的杂志JCB：对纯生信友好还不要版面费！
一文速览 ①JCB的纯生信文章分类 ②投稿建议
一文速览 ①JCP的投稿类型范围 ②纯生信文章分类 ③投稿周期
二.生信思路详解
①数据集筛选原则 ②举例(Case1:肿瘤预后基因; Case2:Risk Score; Case3:耐药基因)
①Case1:预后标志物+免疫浸润; ②Case2:单基因多组学验证生存; ③Case3:基因突变+TMB+免疫浸润
①理清研究方向 ②举例 ③生信分析注意事项
①GEO数据库是什么呢？
②GEO数据库里有多少非肿瘤的数据呢？
③非肿瘤生信GEO的数据挖掘有什么获益呢？
④入门GEO数据挖掘你需要做什么呢？
⑤在线分析网站推荐+生信数据库合集推荐+生信扩展工具合集推荐
三.生信文章详解(标志物&分型&建模)
常规转录组类
(一)表达谱预后
A robust two‐gene signature for glioblastoma survival prediction
Autophagy-related gene P4HB: a novel diagnosis and prognosis marker for kidney renal clear cell carcinoma
Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinomae
Landscape of cancer diagnostic biomarkers from specifically expressed genes
A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma
Identification of PGRMC1 as a Candidate Oncogene for Head and Neck Cancers and Its Involvement in Metabolic Activities
(二)肿瘤免疫微环境或免疫相关类
Immune cell infiltration-based signature for prognosis and immunogenomic analysis in breast cancer
EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients
Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics
Immune-related keygene CLDN10 correlates with lymph node metastasis but predicts favorable prognosis in papillary thyroid carcinoma
Immune gene expression profiling reveals heterogeneity in luminal breast tumors
Nat Commun: 肿瘤淋巴细胞浸润算法预测黑色素瘤生存
An open source automated tumor infiltrating lymphocyte algorithm for prognosis in melanoma
Immune gene expression profiling reveals heterogeneity in luminal breast tumors
(三)ceRNA
Identification of the Key Factors Related to Bladder Cancer by lncRNA-miRNA-mRNA Three-Layer Network
Identification of a potentially functional circRNA–miRNA–mRNA regulatory network for investigating pathogenesis and providing possible biomarkers of bladder cancer
Model-Based Integration Analysis Revealed Presence of Novel Prognostic miRNA Targets and Important Cancer Driver Genes in Triple-Negative Breast Cancers
单细胞转录组类
Single-cell RNA sequencing of immune cells in gastric cancer patients
Single-cell RNA sequencing of human kidney
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report
表观遗传类
(一)m6A
m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer
m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer
(二)甲基化
Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype
干湿结合类
Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival
A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis
The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma
Adipose depot gene expression and intelectin-1 in the metabolic response to cancer and cachexia
基因组类
The pan-cancer landscape of prognostic germline variants in 10,582 patients
Interpretation of somatic POLE mutations in endometrial carcinoma
Identification of Novel CD74-NRG2α Fusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers
Profiles of prognostic alternative splicing signature in hepatocellular carcinoma
NR2F2 Orphan Nuclear Receptor is Involved in Estrogen Receptor Alpha-Mediated Transcriptional Regulation in Luminal A Breast Cancer Cells
非肿瘤生信类
STAT1 and its related molecules as potential biomarkers in Mycobacterium tuberculosis infection
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