单次坐骨神经联合持续股神经阻滞后患儿血液布比卡因浓度：一项前瞻性观察 研究
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Blood Bupivacaine Concentrations After a CombinedSingle-Shot Sciatic Block and a Continuous FemoralNerve Block in Pediatric Patients: A Prospective Observational Study
背景与目的
我们评估了单次坐骨神经和持续股神经阻滞前交叉韧带修复术后患儿血布比卡因浓度。
方 法
在0,5,15,30,60和120分钟以及4,24和48小时分析干血斑点样品的布比卡因含量。在4小时评估点，最高99％的可信区间上限为135 ng / mL。
结 果
所有采样时间内，99％的可信区间上限低于潜在的毒性水平（1500ng / mL）。
结 论
接受布比卡因单次坐骨神经和持续股神经阻滞的患儿局麻药中毒风险非常低
原始文献摘要
Anesth Analg 2017;124:1591–3
We evaluated blood bupivacaine concentrations in children having a single-shot sciatic and continuous femoral blocks after anterior cruciate ligament repair. Dried blood spot samples were analyzed for bupivacaine levels at 0, 5, 15, 30, 60, and 120 minutes and 4, 24, and 48 hours.The highest 99% upper confidence interval limit was 135 ng/mL at the 4-hour evaluation point. The 99% upper confidence interval was below potentially toxic levels (1500 ng/mL) across all sampling times. The risk of local anesthetic toxicity in pediatric patients receiving single-shot sciatic and continuous femoral nerve blocks is very low.
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