⼩剂量罗库溴铵对可视喉镜辅助下快速⽓管插管的影响：随机双盲 对照研究
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The effect of low-dose rocuronium on rapid tracheal intubation using a video laryngoscope A randomized double blind controlled study
背景与目的
本研究旨在探讨⼩剂量罗库溴铵在可视喉镜辅助下快速⽓管插管中
的临床效果。
方 法
本研究将98例⽿⿐喉科⼿术患者随机分为2组：组L(n=49)静脉使
⽤罗库溴铵0.3mg/kg和组C(n=49) 静脉使⽤罗库溴铵0.6mg/kg。罗库溴铵给药后60s，在可视喉镜辅助下进⾏⽓管插管。根据喉镜检查情况、声带位置、插管反应等情况对⽓管插管的整体情况进⾏评估。根据
Cormack-Lehane分级、1次插管成功率和插管时间对插管情况进⾏评
估。
结 果
L组与C组整体插管情况存在显著性差异(p=0.003)。L组⽓管插管
后剧烈反应的发⽣率⾼于C组(p=0.022)，两组间喉镜检查情况和声带位置⽐较差异⽆统计学意义(分别为p=0.145和0.070)。两实验组插管情况,⼿术期间补充罗库溴铵的频率和剂量⽐较差异⽆统计学意义(P>0.05)。
结 论
⼩剂量罗库溴铵⽤于可视喉镜辅助下⽓管插管时整体插管条件差于
常规剂量组。然⽽，当使⽤可视喉镜辅助时，它可以提供临床上可以接受的喉部肌⾁松弛。
原始文献摘要
：Ji SM,Lee JG,Kim S,et al. The effect of low-dose rocuronium on rapid tracheal intubation using a video laryngoscope: A randomized double blind controlled study[J].Medicine (Baltimore) 2018 Jun;97(22)DOI：10.1097/MD.0000000000010921
Background: The aim of this study was to investigate the clinical effectiveness of rocuronium in low doses on conditions during rapid tracheal intubation using video laryngoscope.
Methods:Ninety-eight patients undergoing otolaryngologic surgery were randomly divided into 2 groups: group L using 0.3mg/kg of rocuronium intravenously (n=49) and group C using 0.6mg/kg of rocuronium (n=49). Sixty seconds after rocuronium administration, tracheal intubation was performed using a video laryngoscope. The overall intubation condition was evaluated along with specific conditions, including laryngoscopy condition, vocal cord position, and intubation response. Intubation profiles, including
Cormack–Lehane grade, 1st attempt success rate, and intubation time, were also evaluated.
Results: Overall intubation conditions showed a significant difference between group L and group C (P=.003). Although the incidence of vigorous response after tracheal intubation was higher in group L than in group C (P=.022), laryngoscopy condition and vocal cord position were similar between the 2 groups (P=.145 and .070, respectively). Intubation profiles showed no differences between the 2 groups. The frequency and amount of additional rocuronium administration during surgery were also similar.
Conclusions: Low-dose rocuronium provided significantly worse overall intubation conditions compared to the conventional dose of rocuronium for rapid tracheal intubation. However, when using a video laryngoscope, it may provide clinically acceptable laryngeal muscle relaxation.
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