【阅读理解】成人患者长期接受家庭肠外营养时补充锰的推荐量：支持证据分析

Nutr Clin Pract. 2016 Apr;31(2):180-5.

Recommendations for Manganese Supplementation to Adult Patients Receiving Long-Term Home Parenteral Nutrition: An Analysis of the Supporting Evidence.

Baker B, Ali A, Isenring L.

  • School of Human Movement Studies, University of Queensland, Brisbane, Queensland, Australia.

  • Princess Alexandra Hospital, Brisbane, Queensland, Australia.

  • Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Queensland, Australia.

INTRODUCTION: Manganese (Mn) toxicity is often observed in adult patients receiving long-term home parenteral nutrition (HPN), and differing recommendations on the safe level of Mn administration to these patients have been made in the literature over the past 10 years.

METHODS: This systematic review used the National Health and Medical Research Council (NHMRC) evidence hierarchy to assess the design and strength of individual studies (high I to low IV) and the overall grade of evidence (grade A high to grade D low).

RESULTS: Eight studies met the inclusion criteria. Levels of evidence ranged from high (NHMRC II) to mid-level (III-3). A widespread recommendation in the literature for patients receiving long-term HPN is 55 μg (1 μmol) Mn/d.

CONCLUSION: The recommendation of 55 μg (1μmol) Mn/d is of moderate-strength evidence (NHMRC B grade). There is limited evidence to support not supplementing Mn to patients receiving long-term HPN. Further intervention studies providing high-level evidence (II and above) are required to determine the safety of not supplementing Mn to all patients receiving long-term HPN.

PMID: 26203074

DOI: 10.1177/0884533615591600

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