地佐辛注射液与吗啡注射液治疗中国癌症患者持续癌痛的疗效和安全性比较：Meta分析
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Comparison of the efficacy and safety
between dezocine injection and morphine injection for persistence of pain in Chinese cancer patients: a meta-analysis
背景与目的
关于地佐辛注射液与吗啡注射液治疗癌症患者持续癌痛的疗效和安全性之间的比较已引起争议。因此，对现有的观察性研究进行meta分析，以评价在中国人群中它们之间的关系。
方 法
我们通过PubMed，Web of Science和万方医学在线的数据库对2016年10月前的相关研究进行了综合性的分析。使用随机效应模型计算出95％置信区间（95％CI）的概率比值比（OR） 模型。 包括333个使用地佐辛注射液的患者和321个使用吗啡注射液的患者在内的9个已发表的研究纳入本Meta分析。
结 果
我们的研究结果表明使用地佐辛注射液与吗啡注射液后有效缓疼解痛（EPR）的病例数无明显统计学意义[OR = 0.97,95％CI（0.77-1.22），I2 = 0.0，P（异质性） = 1.000]。 但地佐辛注射液引起的药物不良反应率（ADR）比吗啡注射液低56％，差异有统计学意义[OR = 0.44,95％CI（0.30-0.65），I2 = 0.0，P （异质性）= 0.980]。 研究异质性和发表偏倚之间无相关性。
结 论
综上所述，本meta分析表明地佐辛注射液与吗啡注射液在治疗中国癌症患者持续癌痛的疗效上无显著相关性。 然而，与吗啡注射液相比，地佐辛注射液的ADR较少。
原始文献摘要
Wang L, Liu X, Wang J, Sun Y, Zhang G, Liang L；Comparison of the efficacy and safety between dezocine injection and morphine injection for persistence of pain in Chinese cancer patients: a meta-analysis.Biosci Rep. Jun 8，2017;37(3). pii: BSR20170243. doi: 10.1042/BSR20170243. Print Jun 30，2017.
BACKGROUND AND OBJECTIVE:The association between the efficacy and safety of dezocine injection and morphine injection for persistence of pain in patients with cancer had yielded controversial results. Therefore,we conduct a meta-analysis of existing observational published studies to assess the relationship between them among Chinese.
METHODS:We conducted a comprehensive research from the databases of PubMed,Web of Science, andWan Fang Med Online for the related studies up to October 2016. Summary odds ratio (OR) with 95% confidence interval (95% CI) were calculated with the random effects model. Nine published studies comprising 333 dezocine injection patients and 321 morphine injection patients were included in this meta-analysis.
RESULTS:Our results suggested that there was no statistical significance between dezocine injection and morphine injection at the case number of effective pain relief (EPR) [OR = 0.97, 95% CI (0.77–1.22), I2 = 0.0, P for heterogeneity = 1.000]. However, the rate of adverse drug reaction (ADR) caused by dezocine injection was 56% less than that caused by morphine injection,the difference was statistically significant [OR = 0.44, 95% CI (0.30–0.65), I2 = 0.0, P for heterogeneity = 0.980]. No between-study heterogeneity and publication bias were found.
CONCLUSIONS:In conclusions, this meta-analysis indicates that there is no significant association on the efficacy of persistence of pain in patients with cancer between dezocine injection and morphine injection among Chinese. However, dezocine injection was with less ADR compared with morphine injection.
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