根据甲基化探针信号值把样本分成CIMP组
看到文章 PLoS Genet. 2016 ,提到了 CpG island methylator phenotype (CIMP) subtype
分组的细节
Methylation datasets of 529 TCGA COADREAD samples were obtained from https://tcga-data.nci.nih.gov/tcga/. For the 2000 probes showing the highest variance in the TCGA samples, we made clustered heat maps of β values for only the TCGA samples.
如下:
无法理解的是,这两个组别颜色太接近,不知道作者为什么这样的配色方案选择。
两个重要基因集
主要是上面文献提到的两个参考文章 CpG island promoters of the epigenetic gatekeepers [14] and CIMP-related genes [39].
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