成人肺囊性纤维化加重期间及之后矿物质微量元素水平的变化

Nutr Clin Pract. 2015 Dec;30(6):838-43.

Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis.

Lee MJ, Alvarez JA, Smith EM, Killilea DW, Chmiel JF, Joseph PM, Grossmann RE, Gaggar A, Ziegler TR, Tangpricha V; Vitamin D for Enhancing the Immune System in Cystic Fibrosis Investigators.

Atlanta VA Medical Center, Atlanta, Georgia.

Emory University School of Medicine, Atlanta, Georgia.

Laney Graduate School, Emory University, Atlanta, Georgia.

Children's Hospital Oakland Research Institute, Oakland, California.

Case Western Reserve University School of Medicine, Cleveland, Ohio.

Rainbow Babies and Children's Hospital, Cleveland, Ohio.

University of Cincinnati, Cincinnati, Ohio.

College of Nursing, University of Iowa, Iowa City, Iowa.

University of Alabama at Birmingham, Birmingham, Alabama.

BACKGROUND: Patients with cystic fibrosis (CF) may be at risk for micronutrient depletion, particularly during periods of illness and infection. The purpose of this study was to investigate serum micronutrient status over time in adults with CF initially hospitalized with a pulmonary exacerbation.

MATERIALS AND METHODS: This was an ancillary study of a multicenter trial investigating the role of high-dose vitamin D supplementation in 24 adults with CF (mean age, 29.6 ± 7.3 years). We measured serum concentrations of copper (Cu), iron (Fe), calcium (Ca), magnesium (Mg), potassium (K), and sulfur (S) in subjects at the beginning of a pulmonary exacerbation and again at 3 months.

RESULTS: Serum concentrations of Cu, Fe, and Ca were significantly lower at baseline compared with 3 months following the pulmonary exacerbation (Cu: baseline, 1.5 ± 0.6 vs 3 months, 1.6 ± 0.6 μg/mL, P = .027; Fe: 0.8 ± 0.3 vs 1.3 ± 1.1 μg/mL, P = .026; Ca: 9.7 ± 0.8 vs 10.8 ± 2.0 mg/dL, P = .024). Serum concentrations of K, Mg, and S did not change over time (K: baseline, 4.9 ± 0.3 vs 3 months, 5.1 ± 0.5 mEq/L; Mg: 1.8 ± 0.2 vs 2.0 ± 0.3 mg/dL; S: 1288.6 ± 343 vs 1309.9 ± 290 μg/mL; P > .05 for all).

CONCLUSION: Serum concentrations of Cu, Fe, and Ca increased significantly several months following recovery from acute pulmonary exacerbation in adults with CF. This may reflect decreased inflammation, improved food intake, and/or increased absorption following recovery.

KEYWORDS: calcium; copper; cystic fibrosis; iron; lung; magnesium; micronutrients; potassium; sulfur

PMID: 26078287

PMCID: PMC4701694

DOI: 10.1177/0884533615589991