免疫调节剂在实验模型中对肠屏障动态平衡的作用

Clin Nutr. 2015 Dec;34(6):1080-7.

The role of immunomodulators on intestinal barrier homeostasis in experimental models.

Andrade ME, Araújo RS, de Barros PA, Soares AD, Abrantes FA, Generoso Sde V, Fernandes SO, Cardoso VN.

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

The intestinal epithelium is composed of specialized epithelial cells that form a physical and biochemical barrier to commensal and pathogenic microorganisms. However, dysregulation of the epithelial barrier function can lead to increased intestinal permeability and bacterial translocation across the intestinal mucosa, which contributes to local and systemic immune activation. The increase in these parameters is associated with inflammatory bowel disease, physical exercise under heat stress, intestinal obstruction, ischemia, and mucositis, among other conditions. Lately, there has been growing interest in immunomodulatory nutrients and probiotics that can regulate host immune and inflammatory responses and possibly restore the intestinal barrier. Immunomodulators such as amino acids (glutamine, arginine, tryptophan, and citrulline), fatty acids (short-chain and omega-3 fatty acids and conjugated linoleic acids), and probiotics (Bifidobacterium, Saccharomyces, and Lactobacillus) have been reported in the literature. Here, we review the critical roles of immunomodulatory nutrients in supporting gut barrier integrity and function.

KEYWORDS: Amino acids; Fatty acids; Inflammation; Intestinal mucosa; Probiotics

PMID: 25660317

DOI: 10.1016/j.clnu.2015.01.012