备注：a A disabling deficit is defined as impairments that would prevent the patient from performing essential activities of daily living (eg, bathing, ambulating, toileting, hygiene, and eating) or returning to work.b In the presence of large-vessel occlusion, there are insufficient data to recommend alteplase plus endovascular therapy. Currently, endovascular therapy alone should be considered based on imaging selection criteria.c Single antiplatelet therapy (aspirin, clopidogrel, or ticagrelor) should be held for 24 hours following administration of alteplase.d The DEFUSE-3 trial81 applied a maximum core infarct volume of 70 mL. Patients with greater than this volume were not eligible.e Other criteria for endovascular therapy include a score greater than 5 on the National Institutes of Health Stroke Scale and absence of early infarct signs on CT of the head (ASPECTS score >5).f The American Heart Association acute ischemic stroke guidelines85 recommend using the criteria in the DEFUSE-381 and DAWN80 trials for mechanical thrombectomy in the extended 6- to 24-hour time window.g Anticoagulants would be appropriate for cardioembolic and hypercoagulable causes of ischemic stroke or transient ischemic attack such as atrial fibrillation.图2：急性缺血性卒中的诊断和分型：
文献出处：JAMA. 2021 Mar 16;325(11):1088-1098. doi: 10.1001/jama.2020.26867.Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke: A Review
