Favorskii重排
可以烯醇化的α-卤代酮在烷氧基,羟基或胺催化下重排分别生成酯,羧酸或酰胺的反应。
环状底物的Favorskii重排
反应机理
烯醇化的α-卤代酮进行分子内的SN2反应得到环丙酮中间体,亲核试剂进攻环丙酮的羰基进行重排生成产物。
反应实例
参考文献
1. (a) Favorskii, A. E. J. Prakt. Chem. 1895, 51, 533563. Aleksei E. Favorskii
(1860-1945), born in Selo Pavlova, Russia, studied at St. Petersburg State University, where he became a professor since 1900. (b) Favorskii, A. E. J. Prakt. Chem. 1913,88, 658.
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编译自:J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, Favorskii rearrangement7,page 239-241.