吸入麻醉后恢复的年龄相关差异：回顾性研究。
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Age-related differences in recovery from inhalational anesthesia: a retrospective study.
背景
理解不同年龄患者的麻醉要求很重要。 然而，人们对吸入麻醉药的年龄相关性恢复差异知之甚少。 在这项回顾性研究中，我们比较了不同年龄人群使用三种吸入麻醉药后的恢复差异。
方 法
将患者作为三个年龄组进行研究，这些年龄组可以被分为在全身麻醉下使用吸入麻醉剂的儿科（<15岁），成人（15-64岁）和老年患者（> 65岁）。 记录麻醉和手术时间，药物呼气末浓度，第一次运动的时间，睁眼时间，身体运动、拔管和排泄时间。数据使用Kruskal-Wallis检验和Steel-Dwass多重比较进行分析。
结 果
本研究共纳入594例患者。 在吸入麻醉药七氟烷、异氟醚和地氟醚中，全麻复苏率在各年龄组之间无显着性差异（P> 0.05）。 地氟烷组的恢复速度显着快于其他吸入麻醉组的恢复5-40％。地氟醚组中，儿童和成人组的恢复速度比老年人快20％。 儿童组吸入药物浓度显着高于成人和老年人组。
结 论
在目前的研究中，我们发现地氟醚恢复速度要快于其他吸入麻醉剂，年轻患者的恢复速度要快于其他年龄段患者。
原始文献摘要
INTRODUCTION:
It is important to understand the anesthetic requirements of elderly patients. However, little is known about age-related recovery from inhalational anesthetics. In this retrospective study, we compared age-related differences in recovery from three inhalational anesthetics in elderly subjects.
METHODS:
Patients were investigated as three age groups which can be defined as age ranges pediatric (< 15 years), adult (15-64 years), and elderly patients ( > 65 years) under general anesthesia using inhalational anesthetics. Anesthesia and surgery times, drug end-tidal concentrations, the time to first movement, time to eye opening, body movement, extubation, and discharge were recorded. The data were analyzed using a Kruskal-Wallis test and Steel-Dwass multiple comparisons.
RESULTS:
A total of 594 patients were included in the study. In inhalational anesthetics such as sevoflurane, isoflurane, or desflurane, recovery from general anesthesia was not significantly different among age groups (P > 0.05). In inhalational group, recovery was significantly 5-40% faster in desflurane group than in other inhalational anesthetics groups (P < 0.05). There were 20% faster recovery in pediatric and adult groups withdesflurane than in elderly with desflurane group. Drug end-tidal inhalational concentrations in pediatric group were significantly higher than that in adult and elderly groups of all inhalational anesthetics, respectively (P < 0.05).
CONCLUSION:
In the current study, we have found that recovery from desflurane was faster in younger patients than in other inhalational anesthetics and aged patients.
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