高脂饮食如何影响大脑时钟？ | 热心肠日报
[IF:9.412]
通过营养挑战重塑眼交叉上核和前额叶皮层的昼夜节律代谢
10.1073/pnas.2016589117
11-10, Article
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Food is a powerful entrainment cue for circadian clocks in peripheral tissues, and changes in the composition of nutrients have been demonstrated to metabolically reprogram peripheral clocks. However, how food challenges may influence circadian metabolism of the master clock in the suprachiasmatic nucleus (SCN) or in other brain areas is poorly understood. Using high-throughput metabolomics, we studied the circadian metabolome profiles of the SCN and medial prefrontal cortex (mPFC) in lean mice compared with mice challenged with a high-fat diet (HFD). Both the mPFC and the SCN displayed a robust cyclic metabolism, with a strikingly high sensitivity to HFD perturbation in an area-specific manner. The phase and amplitude of oscillations were drastically different between the SCN and mPFC, and the metabolic pathways impacted by HFD were remarkably region-dependent. Furthermore, HFD induced a significant increase in the number of cycling metabolites exclusively in the SCN, revealing an unsuspected susceptibility of the master clock to food stress.
First Authors:
Paola Tognini
Correspondence Authors:
Paola Tognini,Pierre Baldi
All Authors:
Paola Tognini,Muntaha Samad,Kenichiro Kinouchi,Yu Liu,Jean Christophe Helbling,Marie-Pierre Moisan,Kristin L Eckel-Mahan,Pierre Baldi,Paolo Sassone-Corsi