盘点全球NMN人体临床试验进展
Click on the blue text above follow GeneChic
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盘点全球
NMN人体临床试验进展
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Review of global NMN
human clinical trials
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NMN在人体内的作用究竟如何?
What is the role of NMN
in the human body?
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全球规模最大的NMN
人体临床试验项目正式启动
The world's largest human clinical trial
of NMN officially launched
注册时间:2020年11月
研究单位:广州体育学院、赛立复(中国)
参与人数:100人
实验时间:6周 12周,2022年1月截止
参与对象:50~70岁,糖尿病前期男女各半
实验方法:随机双盲安慰剂对照
实验目的:NMN对中老年人糖尿病前期患者的作用效果(安全性及有效性)
实验结果:未公布
详情链接:http://www.chictr.org.cn/showproj.aspx?proj=64030
Registration time: November 2020
Research Institute: Guangzhou Sport University, Sailifu (China)
Number of participants: 100
Experiment time: 6 weeks 12 weeks, until January 2022
Participants: 50-70 years old, half male and half female in prediabetes
Methods: randomized, double-blind, placebo-controlled study
Objective: To investigate the effect of NMN on middle-aged and elderly patients with pre diabetes mellitus (safety and effectiveness)
Results: unannounced
Details link: http://www.chictr.org.cn/showproj.aspx?proj=64030
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盘点日本NMN人体临床试验验
Review of human clinical trials
of NMN in Japan
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1、NMN人体Ⅰ 期临床试验
注册时间:2016年3月
研究单位:日本庆应大学医学院
实验目的:NMN在健康人中的安全性评价Ⅰ期研究。
临床试验评估代谢综合征相关参数,以发展NMN作为食品功能要求。
实验时间:6个月
参与对象:10名,年龄40~60岁,健康男性
实验结论:未公开
详情链接:https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024575
1. NMN human phase I clinical trial
Registration time: March 2016
Research Institute: School of medicine, Keio University, Japan
Objective: phase I study on safety evaluation of NMN in healthy people. Clinical trials evaluate metabolic syndrome related parameters to develop NMN as a food functional requirement.
Experiment time: 6 months
Participants: 10 healthy men aged 40-60
Experimental conclusion: undisclosed
Details link: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024575
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2、NMN人体Ⅱ 期临床试验
注册时间:2017年12月
研究单位:日本庆应大学医学院
实验目的:NMN在健康人群中的安全性评价Ⅱ期研究。
实验时间:1年,2018年12月截止
参与对象:30名,年龄40-60岁,健康男性
实验结论:未公开
详情链接:https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034931
2. NMN human phase II clinical trial
Registration time: December 2017
Research Institute: Keio University School of Medicine, Japan
Experimental purpose: Phase II study of the safety evaluation of NMN in healthy people
Experiment time: 1 year, until December 2018
Participants: 30 healthy men, aged 40-60 years old
Experimental conclusion: undisclosed
Details link: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034931
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3、NMN对老年人身体成分的影响
注册时间:2019年6月
研究单位:东京大学医院
实验目的:NMN对老年人身体成分的影响
实验方法:随机双盲安慰剂对照
实验时间:3个月
参与对象:42名,65岁以上,健康男性,250mg/天
实验结论:未公开
详情链接:https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000040733
3. The influence of NMN on the body composition of the elderly
Registration time: June 2019
Research Institute: The Hospital of Tokyo University
Experimental purpose: The effect of NMN on the body composition of the elderly
Experimental method: randomized double-blind placebo controlled
Experiment time: 3 months
Participants: 42 people, over 65 years old, healthy men, 250mg/day
Experimental conclusion: undisclosed
Details link: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000040733
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4、NMN抗皱作用效果评价
4、NMN抗皱作用效果评价
注册时间:2020年12月
研究单位:日本临床试验协会
参与人数:15人
参与对象:35-59岁,健康女性
实验方法:平行随机
实验目的:含人体干细胞成分及NMN美容精华的抗皱作用
实验时间:1个月
实验结果:未公布
详情链接:https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048893
4. Evaluation of the anti-wrinkle effect of NMN
Registration time: December 2020
Research Institute: Japan Clinical Trial Association
Number of participants: 15
Participants: 35-59 years old, healthy women
Experimental method: parallel random
Experimental purpose: to evaluate the anti-wrinkle effect of beauty essence containing human stem cells and NMN
Experiment time: 1 month
Experimental results: unannounced
Details link: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048893
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5、过量服用NMN安全性评估试验
注册时间:2021年1月
相关单位:日本制药食品公司
参与人数:32人
参与对象:20-65岁,男性和女性
实验方法:随机双盲
实验目的:人类过量摄入含NMN食物的安全性评估的验证研究
实验时间:1个月
实验结果:未公布
详情链接:https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049188
5. Overdose NMN safety evaluation test
Registration time: January 2021
Related department: Japan Pharmaceutical Food Company
Number of participants: 32
Participants: 20-65 years old, male and female
Experimental method: random double blind
Experimental purpose: Validation study on the safety assessment of human over-intake of food containing NMN
Experiment time: 1 month
Experimental results: unannounced
Details link: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049188
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首个发布实验结果的
随机双盲NMN人体临床试验
注册时间:2017年5月
研究单位:华盛顿大学医学院
参与人数:25人
参与对象:55-75岁,糖尿病前期女性
实验方法:随机双盲安慰剂对照
实验目的:NMN对心血管代谢功能的影响
实验时间:10周
结果发布时间:2021年4月
实验结果:NMN可以增强受试人群肌肉组织的胰岛素敏感性
详情链接:https://clinicaltrials.gov/ct2/show/NCT03151239
[The first randomized double-blind human clinical trial of NMN to release experimental results]
Registration time: May 2017
Research institute: University of Washington School of Medicine
Number of participants: 25
Participants: 55-75 years old, pre-diabetic women
Experimental method: randomized double-blind placebo controlled
Experimental purpose: The effect of NMN on cardiovascular metabolism
Experiment time: 10 weeks
Results release time: April 2021
Experimental results: NMN can enhance the insulin sensitivity of the muscle tissue of the test population
Details link: https://clinicaltrials.gov/ct2/show/NCT03151239
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