2020年医学生信分析别人都在用哪些思路?

Hello,各位小伙伴们,我们是科研菌!!

"科研菌"团队每天为您提供高质量的原创科研论文精读, 期刊投稿, 资源分享和文章;每天一篇文章深度剖析,给您更开阔的科研思路

只需长按识别二维码,即可一键关注,开启你的高效科研之旅

天科研菌为大家带来2020年3月生信套路合集,一起看下Outline

关注科研菌公众号后台回复“2020即可获得科研菌2020年最新医学生信套路合集PDF版!

点击下方任一链接,即可跳转该文章的详细解读!!


一. 生信友好杂志详解

1.被“灌水”的Aging(IF=5.515)还能不能投?

带你了解 

①Aging现在的状况如何?

②Aging成了纯生信灌水的乐园?

2.即将突破5分的Frontiers in Oncology是灌水杂志吗?

带你了解 

①Front Oncol发表的生信文章的文章类型为哪几类?

②纯生信文章的发表周期如何?

3.马上4分年刊近2000的杂志JCB:对纯生信友好还不要版面费!

一文速览 

①JCB的纯生信文章分类 

②投稿建议

4.年刊量3000篇预计5+分的JCP

一文速览 

①JCP的投稿类型范围 

②纯生信文章分类 

③投稿周期

5.推荐一本生信友好并且最快1月接受的5+分杂志


二.生信思路详解

1.如何筛出一篇5分文章的核心基因

①数据集筛选原则 

②Case1: 肿瘤预后基因

③Case2: Risk Score

④Case3: 耐药基因


2.筛到5分的核心基因以后你可以怎么做?

①Case1:预后标志物+免疫浸润

②Case2:单基因多组学验证生存

③Case3:基因突变+TMB+免疫浸润


3.国自然前期研究基础不足?你可以这样补一些生信分析

①理清研究方向 

②举例 

③生信分析注意事项


三.生信文章详解(标志物&分型&建模)

常规转录组类

(一)表达谱预后

胶质瘤双基因预后标志物就能3+了?

A robust two‐gene signature for glioblastoma survival prediction


肾癌之自噬基因预后预测模型发5+分

Autophagy-related gene P4HB: a novel diagnosis and prognosis marker for kidney renal clear cell carcinoma


肾癌EMT基因预后标志物发5+分

Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinomae


9+纯生信泛癌预后标志物筛选

Landscape of cancer diagnostic biomarkers from specifically expressed genes


(二)肿瘤免疫微环境或免疫相关类

围观:为什么别人的免疫浸润能发9+分?

Immune cell infiltration-based signature for prognosis and immunogenomic analysis in breast cancer


5+易学套路: 基因突变+TMB+免疫浸润

EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients


纯生信4+膀胱癌免疫微环境思路分享

Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics


一学就会的5+分免疫基因与乳腺癌异质性分析

Immune gene expression profiling reveals heterogeneity in luminal breast tumors


(三)ceRNA

膀胱癌ceRNA的3+分思路

Identification of the Key Factors Related to Bladder Cancer by lncRNA-miRNA-mRNA Three-Layer Network


单细胞转录组类

在Aging上发表的胃癌单细胞测序做了什么?

Single-cell RNA sequencing of immune cells in gastric cancer patients


仅3个单细胞测序样本纯分析也发6分!

Single-cell RNA sequencing of human kidney


纯生信新冠思路:单细胞测序分析口腔粘膜ACE2表达

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa


表观遗传类

(一)m6A

15+分的纯生信:胃癌m6A和肿瘤免疫微环境

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer


即将11+分的JHO:泛肿瘤中m6A和5mC与肿瘤免疫特征

Identification of cross-talk between m6A and 5mC regulators associated with onco-immunogenic features and prognosis across 33 cancer types


(二)甲基化

5+乳腺癌表观遗传深度剖析

Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype

干湿结合类

干湿结合上6+高渗基因与透明细胞肾癌预后

Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival


干湿结合的miRNA调控网络发7+也不难

A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis


基因组类

突变预后

Genome Med一文带你学会胚系突变与泛癌预后思路

The pan-cancer landscape of prognostic germline variants in 10,582 patients


一文就懂子宫内膜癌的POLE突变如何发病理学顶刊

Interpretation of somatic POLE mutations in endometrial carcinoma

科研菌始终都在,陪你度过漫漫科研路

希望志同道合的小伙伴就像科研“菌”一样不断裂变,越来越多

(0)

相关推荐