体内微生物协同进化增强宿主抵抗力 | 热心肠日报
In vivo microbial coevolution favours host protection and plastic downregulation of immunity
体内微生物协同进化有利于宿主保护和下调免疫功能的可塑性
10.1093/molbev/msaa292
11-12, Article
Abstract & Authors:展开
Abstract:收起
Microbiota can protect their hosts from infection. The short timescales in which microbes can evolve presents the possibility that ‘protective microbes’ can take-over from the immune system of longer-lived hosts in the coevolutionary race against pathogens. Here, we found that coevolution between a protective bacterium (Enterococcus faecalis) and a virulent pathogen (Staphylococcus aureus) within an animal population (Caenorhabditis elegans) resulted in more disease suppression than when the protective bacterium adapted to uninfected hosts. At the same time, more protective E. faecalis populations became costlier to harbour and altered the expression of 134 host genes. Many of these genes appear to be related to the mechanism of protection, reactive oxygen species production. Crucially, more protective E. faecalis populations downregulated a key immune gene, sodh-1, known to be effective against S. aureus infection. These results suggest that a microbial line of defence is favoured by microbial coevolution and may cause hosts to plastically divest of their own immunity.
First Authors:
Suzanne A Ford,Suzanne A Ford
Correspondence Authors:
Suzanne A Ford,Suzanne A Ford
All Authors:
Suzanne A Ford,Suzanne A Ford