七氟醚与地氟醚麻醉对术后咽喉痛影响的比较：前瞻性随机试验
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Influence of intraoperative sevoflurane or desflurane on postoperative sore throat: a prospective randomized study
背景与目的
全身麻醉气管插管可导致术后咽喉痛。本研究旨在评估七氟醚和地氟醚对全身麻醉患者术后咽喉痛发生率的影响。
方 法
全身麻醉下行骨科下肢手术的96名患者，随机分配到七氟醚组或地氟醚组。七氟醚组（n = 48）：术中使用七氟醚维持麻醉；地氟烷组（n = 48）：术中使用地氟烷维持麻醉。记录患者术后咽喉的发生率、急需镇痛药患者的数量和镇痛药的要求。
结 果
七氟醚组术后咽喉痛的总发生率低于地氟醚组[21（44％）vs 32（67％），p = 0.024]。术后4小时七氟醚组咽喉痛发生率低于地氟醚组[6（13％）vs 18（38％），p = 0.005]。七氟醚组急需镇痛药的患者数量较少[25（52％）与36（75％），p = 0.020]。七氟醚组镇痛药需求量也较低（30±37 mg vs. 47±40 mg，p = 0.031）。
结 论
本研究表明：与地氟醚麻醉相比，七氟醚麻醉患者咽喉痛的发生率较低。
原始文献摘要
Park J H , Lee Y C , Lee J , et al. Influence of intraoperative sevoflurane or desflurane on postoperative sore throat: a prospective randomized study[J]. Journal of Anesthesia.2019.
PURPOSE
Tracheal intubation for general anesthesia causes postoperative sore throat. The purpose of this study was to evaluate the effect of sevoflurane and desflurane on prevalence of postoperative sore throat in patients after general anesthesia.
METHODS
Ninety-six patients scheduled for orthopedic lower extremity surgery under general anesthesia were assigned to sevoflurane group or desflurane group. In the sevoflurane group (n = 48), sevoflurane was used as a maintenance anesthetic agent. In the desflurane group (n = 48), desflurane was used. Prevalence of sore throat, number of patients with rescue analgesics, and analgesics requirements were evaluated.
RESULTS
The overall prevalence of postoperative sore throat in the sevoflurane group was lower than that in the desflurane group [21 (44%) vs. 32 (67%), p = 0.024]. The prevalence of sore throat at postoperative 4 h in the sevoflurane group was lower than that in the desflurane group [6 (13%) vs. 18 (38%), p = 0.005]. The number of patients requiring rescue analgesics was lower in the sevoflurane group [25 (52%) vs. 36 (75%), p = 0.020]. The requirement of diclofenac was also lower in the sevoflurane group (30 ± 37 mg vs. 47 ± 40 mg, p = 0.031).
CONCLUSIONS
We have shown that sevoflurane was associated with less frequent sore throat than desflurane in patients undergoing orthopedic lower extremity surgery.
麻醉学文献进展分享
贵州医科大学高鸿教授课题组
翻译：符校魁 编辑：何幼芹 审校：王贵龙