光荣榜丨长三角肺癌协作组马胜林教授团队历届国际会议大会发言汇总

● 西湖肺癌 ●

●●●West Lake Lung Cancer●●●

西湖肺癌2015-至今国际会议大会发言共计10项(其中WCLC 6项,ACHO 3项,ICI 1项)

西湖肺癌

国际会议Oral Presentation
2015WCLC: Multiplexing serum proteins and circulating autoantibody for detection of lung cancer (ORAL39.01)
2015WCLC: Identification of miRNAs as biomarkers for early diagnosis of lung cancers (ORAL39.05)
2015WCLC: Acute radiation pneumonitis in lung cancer treated with volumetric modulated arc therapy (MINI33.04)
2015WCLC: Impact of ABCG2 polymorphisms on the  clinical outcome of TKIs therapy in Chinese advanced non-small-cell lung cancer patients (MINI05.02)
2018ACHOClinical practice of hyperthermiain cancer treatment (Oral 06)
2018ACHO: Consolidation hyperthermic intraperitoneal perfusion chemotherapy and intravenous chemotherapy following radical surgery in the treatment of advanced gastric cancer (Oral 16)
2018ACHO: Microwave hyperthermia increases sensitivity to radiation in highly invasive human non-small cell lung cancer cells (Oral 29)
2019ICI: The second generation of Tyrosine Kinase Inhibitor Afatinib controls inflammationby regulating NLRP3 inflammasome activation (900)
2021WCLC:Peripheral CD8+T cells predicts immune-related adverse events and survival in advanced non-small cell lung cancer treated with immunotherapy (MA09.03)
2021WCLC:Integrating genomic and transcriptomic features predict the recurrence risk of stage IA non-small cell lung cancer (MA08.05)
临床试验类

Acta Pharmacol Sin Phase II trial of gemcitabine plus cisplatin in patients with advanced non-small cell lung cancer Sheng-lin Ma(2010)

Int J Hyperthermia Intracavity hyperthermia in nasopharyngeal cancer: a phase III clinical study Sheng-lin Ma(2010)

Lung Cancer Concomitant chemoradiotherapy using pemetrexed and carboplatin for unresectable stage III non-small cell lung cancer (NSCLC):Preliminary results of a phase II study Sheng-lin Ma(2011)

Lancet Oncol Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial Sheng-lin Ma(2012)

Jpn J Clin Oncol Efficacy of erlotinib in previously treated patients with advanced non-small cell lung cancer: analysis of the Chinese subpopulation in the TRUST study  Sheng-lin Ma(2015)

J Thorac Oncol  Final overall survival results from a phase III, randomized,

placebo-controlled, parallel-group study of gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804)  Sheng-lin Ma(2015)

BMC Cancer A phase II study of Endostatin in combination with paclitaxel, carboplatin, and radiotherapy in patients with unresectable locally advanced non-small cell lung cancer Sheng-lin Ma(2016)

J Thorac Dis A phase II study of concurrent nab-paclitaxel/carboplatin combined with thoracic radiotherapy in locally advanced squamous cell lung cancer Sheng-lin Ma(2019)

Lung Cancer A phase III, randomized, double-blind, placebo-controlled, multicenter study of fruquintinib in Chinese patients with advanced nonsquamous non-small-cell lung cancer-the FALUCA study Sheng-lin Ma(2020)

Transl Lung Cancer Res Biosimilar candidate IBI305 plus paclitaxel/carboplatin for the treatment of non-squamous non-small cell lung cancer Sheng-lin Ma(2020)

Int J Radiat Oncol Biol Phys Erlotinib versus Etoposide/Cisplatin with radiation therapy in unresectable stage III Epidermal Growth Factor Receptor mutation-positive non-small cell lung cancer:A multicenter,randomized,open-label,phase 2 trial  Sheng-lin Ma(2020)

转化研究类

EBioMedicine Multiplexed serum biomarkers for the detection of lung cancer  Sheng-lin Ma (2016)

Cancer Commun Epidermal growth factor receptor (EGFR) T790M mutation identified in plasma indicates failure sites and predicts clinical prognosis in non-small cell lung cancer progression during first-generation tyrosine inhibitor therapy:a prospective observational study Sheng-lin Ma(2018)

Tranl Lung  Cancer Res The prognostic value of longitudinal circulating tumor DNA profiling during osimertinib treatment  Sheng-lin Ma(2021)

J Biol Chem  Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphhatidylinositide 3-kinase/Akt/HDM2 pathway Sheng-lin Ma (2009)

Cell Res s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide  Sheng-li Ma (2020)

科技成果奖励汇总

化疗药物敏感性检测试剂盒的开发 苏丹,马胜林,曹江,刘鹏,邓清华,许沈华,张沂平,许亚萍,赵怀(2010年浙江省医药卫生科技二等奖)

软组织肉瘤术后中置管后装治疗联合热疗的临床研究 李涛,谢尚闹,马胜林,狄小云,胡福军,孟旭莉,丁小文,陈杰,莫文菊,吴梅娟(2010年浙江省医药卫生科技三等奖)

切除修复交叉互补基因(ERCC1)反义核酸对肺癌顺铂耐药逆转的初步研究 马胜林,吕汪霞,高赟,苏丹,应莉莎(2011年浙江省医药卫生科技三等奖)

用于肺癌早期诊断的血清标志物的发现与应用 毛伟敏,郑智国,凌志强,周星明,牟瀚舟,马胜林,赵宏光,蒋立明,徐海苗,姚东(2012年浙江省医药卫生科技二等奖)

肺癌早期诊断及个体化治疗 毛伟敏,马胜林苏丹许亚萍郑智国邓清华凌志强林能明卢红阳王国付管卫徐海苗孙才兴(2012年浙江省科技进步二等奖)

肺癌综合诊治技术创新与应用 毛伟敏,张永奎陈明马胜林苏丹许亚萍凌志强(2013中国抗癌协会科技奖二等奖)

热休克胃癌患者腹水来源的exosomes的抗肿瘤效应 钟海均,马胜林,杨云山,修方明,封巍,顾琳慧(2013年浙江省医药卫生科技三等奖)

局限期小细胞肺癌放化综合治疗模式优化策略 马胜林,夏冰,傅小龙,卢红阳,吴侃,蔡旭伟,赵如平,王冰,王雍(2014年杭州市科技进步一等奖)

功能影像与分子靶向引导胸部肿瘤精准放疗 袁双虎,蒋晓东夏冰胡旭东李明焕刘宁于清溪赵伟周波(2015年山东省科技进步二等奖)

局限期小细胞肺癌放化综合治疗模式优化策略 马胜林,夏冰,卢红阳,傅小龙,毛伟敏,吴侃,朱正飞,徐晓,赵如平,王冰(2016年浙江省科技进步三等奖)

食管癌放疗参数优化和疗效监测的研究 吴式琇,宋涛,夏冰,景钊,张红芳,陈鹏(2016年浙江省科技进步三等奖)

肺癌个体化放疗的创新与临床应用 袁双虎,于金明蔡旭伟夏冰陈兆秋杨文锋胡旭东李明焕(2016中华医学科技三等奖)

新型分子标记物的筛选及对早期肺癌诊断与预后的指导价值 马胜林,张仕蓉,王孝举,王闻哲,朱鲁程,贾静,徐如君,江洪,王利民,吴侃,张静静,金儿,厉力华(2017年浙江省医药卫生科技奖一等奖)

清肺合剂在肺癌临床综合治疗中的研究与应用 毛伟敏,林能明,吴永江,方罗,马胜林,李清林,张爱琴,章红燕,黄萍,姚庆华,刘雪松,洪卫,芦柏震(2017年浙江省中医药科学技术奖一等奖)

肺癌放疗核心技术的建立和临床应用 傅小龙,蒋国梁,冯雯,夏冰,王艳阳,朱正飞,张琴(2017年上海市医学科技一等奖)

新型分子标记物的筛选及对早期肺癌诊断与预后的指导价值 马胜林,张仕蓉,王孝举,王闻哲,朱鲁程(2017中国抗癌协会科技奖三等奖)

肺癌综合诊疗关键技术创新与临床推广应用 毛伟敏,马海涛,胡坚,马胜林,陶敏,苏丹,谢宇锋,许亚萍,张沂平,凌志强,郑智国,黄海涛,卢红阳,范云,宋正波,徐海苗,陈文虎,倪斌,张翀(2017教育部科学技术进步二等奖)

MicroRNA在甲状腺乳头状癌侵袭性行为中的相关性研究 丁金旺,罗定存俞正伟王克义张仕蓉余道军张卧(2017年杭州市科技进步二等奖)

MicroRNA在甲状腺乳头状癌侵袭性行为中的相关性研究 丁金旺,罗定存俞正伟王克义张仕蓉余道军张卧彭友潘钢,陈斌,王炜(2017年浙江省医药卫生科技三等奖)

肺癌放疗核心技术的建立及临床应用 傅小龙,蒋国梁,冯雯,夏冰,王艳阳,朱正飞,张琴,陈桂圆,李玲,蔡旭伟(2018中华医学科技奖二等奖)

肿瘤热疗临床应用体系构建及关键技术  马胜林,吴稚冰,张仕蓉,朱鲁程,李夏东,赵妍妍,胡润磊(2020年浙江省科技进步三等奖)

实验室介绍

浙江省临床肿瘤药理与毒理学研究重点实验室于2019年获浙江省科技厅批准建设,目前是浙江省医院药学领域第一个获批的省级重点实验室。现有固定研究人员48人,其中博士30人,硕士11人,副高以上职称或具有博士学位人员比例为83.33%。团队中有享受国务院特殊津贴专家1名,浙江省有突出贡献中青年专家2名,浙江省卫生领军人才2名,浙江省“151”人才4名。

实验室围绕临床抗肿瘤药物药理及毒理相关科学问题,形成了三个稳定的研究内容:

(1)抗肿瘤药物脏器和皮肤毒性干预及相关分子靶标研究。

(2)抗肿瘤药物联合放射治疗致组织器官损伤的干预及相关分子靶标研究,

(3)肿瘤微环境与肿瘤放化疗抵抗的特异性药物靶点与药物干预进行的研究。

根据PI的主攻方向,在每个研究内容下面设立了多个研究方向。

本实验室拥有一只职称、学历、年龄结构合理、立足基础临床转化的优质队伍,具有良好的人才培养模式和科研基地,现有实验面积2500平方,拥有较多的先进仪器和设备,设备总价值达3615.18万元。2020年度:承担国家级课题、省部级课题近20项,横向课题16项,总计费4000余万元;获得省部级进步奖1项;发表文章近40篇,单篇最高影响因子为20.507;出版专著1本,获得5项专利授权;主持及参与编写专家共识2项。

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