力保肪宁中长链脂肪乳可以显著提高左心室收缩力

　　2016年2月，韩国麻醉学会官方期刊《韩国麻醉学杂志》发表了韩国国立庆尚大学医院麻醉学与疼痛医学科、韩国东亚大学医学院解剖学与细胞生物学系、韩国东亚大学医学院线粒体中枢调节研究中心、韩国首尔国立大学盆唐医院麻醉学与疼痛医学科、韩国国立庆尚大学医学院健康科学研究所的研究论文报告，发现力保肪宁中长链脂肪乳在离体大鼠心脏模型中，可以通过提高细胞内钙水平，显著增加左心室收缩压。

Korean J Anesthesiol. 2016 Feb;69(1):57-62.

Lipofundin MCT/LCT 20% increase left ventricular systolic pressure in an ex vivo rat heart model via increase of intracellular calcium level.

Park J, Kim YA, Han JY, Jin S, Ok SH, Sohn JT, Lee HK, Chung YK, Shin IW.

Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea.

Department of Anatomy and Cell biology, Dong-A University College of Medicine and Mitochondria Hub Regulation Center, Busan, Korea.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.

BACKGROUND: Lipid emulsions have been used to treat various drug toxicities and for total parenteral nutrition therapy. Their usefulness has also been confirmed in patients with local anesthetic-induced cardiac toxicity. The purpose of this study was to measure the hemodynamic and composition effects of lipid emulsions and to elucidate the mechanism associated with changes in intracellular calcium levels in myocardiocytes.

METHODS: We measured hemodynamic effects using a digital analysis system after Intralipid and Lipofundin MCT/LCT were infused into hearts hanging in a Langendorff perfusion system. We measured the effects of the lipid emulsions on intracellular calcium levels in H9c2 cells by confocal microscopy.

RESULTS: Infusion of Lipofundin MCT/LCT 20% (1 ml/kg) resulted in a significant increase in left ventricular systolic pressure compared to that after infusing modified Krebs-Henseleit solution (1 ml/kg) (P = 0.003, 95% confidence interval [CI], 2.4-12.5). Lipofundin MCT/LCT 20% had a more positive inotropic effect than that of Intralipid 20% (P = 0.009, 95% CI, 1.4-11.6). Both lipid emulsion treatments increased intracellular calcium levels. Lipofundin MCT/LCT (0.01%) increased intracellular calcium level more than that of 0.01% Intralipid (P < 0.05, 95% CI, 0.0-1.9).

CONCLUSIONS: These two lipid emulsions had different inotropic effects depending on their triglyceride component. The inotropic effect of lipid emulsions could be related with intracellular calcium level.

KEYWORDS: Calcium; Heart; Intralipid; Lipofundin; Myocardial contraction

PMID: 26885303

DOI: 10.4097/kjae.2016.69.1.57