特邀述评：骨骼肌减少症在临床上的发生率及其相关结局

Nutr Clin Pract. 2016 Feb;31(1):40-8.

Prevalence of Sarcopenia and Associated Outcomes in the Clinical Setting.

Peterson SJ, Braunschweig CA.

Rush University Medical Center, Chicago, Illinois.

University of Illinois at Chicago, Illinois.

Sarcopenia refers to age-associated decrease in muscle mass and function. The condition was originally described in the elderly, but emerging evidence suggests that it is also a concern among the chronically ill nonelderly. Currently there are a number of definitions for diagnosing sarcopenia; however, in the clinical setting, abdominal computed tomography (CT) scans completed for diagnostic purposes can be utilized to identify CT-defined sarcopenia. Recent studies suggest that prevalence of CT-defined sarcopenia is high among chronically ill patients, ranging from 15%-50% in patients with cancer, 30%-45% with liver failure, and 60%-70% for critically ill patients in the intensive care unit. Depleted muscle mass is associated with infectious complications, prolonged duration of mechanical ventilation, longer hospitalization, greater need for rehabilitation care after hospital discharge, and higher mortality. In consideration of the growing population of older adults with multiple comorbidities, more research is needed to identify sarcopenia and develop interventions that are directed at attenuating or reversal muscle loss.

KEYWORDS: body composition; computed tomography; malnutrition; sarcopenia

PMID: 26703961

DOI: 10.1177/0884533615622537