补充菜籽油可缓解肥胖男性的脂肪肝 | 热心肠日报
补充膳食菜籽油可减轻肥胖男性的肝性脂肪变性——一项随机对照试验
10.1002/mnfr.202000419
09-13, Article
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Scope: Effective treatment for obesity associated non‐alcoholic fatty liver disease (NAFLD) is limited. Dietary supplementation of n‐3 polyunsaturated fatty acids, specifically alpha linolenic acid (ALA), can resolve intrahepatic lipid content (IHL). This study investigates the effect of daily supplementation of either refined rapeseed (RA), containing high amounts of ALA, or refined olive (OL) oil on IHL and glucose metabolism in NAFLD patients.
Methods and results: 27 obese men consumed an isocaloric diet including either 50 g of RA or OL daily for 8 weeks. Hepatic proton magnetic resonance spectroscopy, hyperinsulinemic–euglycemic clamp studies and blood tests are performed before and at the end of the study. At 8 weeks a significant reduction in IHL is observed for RA (13.1 ± 1.6 before versus 11.1 ± 1.6% after intervention) versus OL (13.3 ± 2.5 before versus 15.7 ± 2.7% after intervention). For RA, a 21% reduction (P < 0.02) in serum free fatty acids (FFA) and a 1.68‐fold increase (P = 0.03) of serum interleukin‐6 (IL‐6) is observed after 8 weeks.
Conclusion: RA has a beneficial effect on hepatic lipid metabolism as shown by reduced IHL and serum FFA. RA induced IL‐6 production seems to be liver protective confirming previous results.
First Authors:
Michael Kruse
Correspondence Authors:
Michael Kruse
All Authors:
Michael Kruse,Margrit Kemper,Sofiya Gancheva,Martin Osterhoff,Dirk Dannenberger,Daniel Markgraf,Jürgen Machann,Johannes Hierholzer,Michael Roden,Andreas F H Pfeiffer