刘学波团队：膳食纤维缓解肥胖雌鼠的产后抑郁 | 热心肠日报
高膳食纤维摄入缓解产前肥胖诱导的产后抑郁：肠道菌群及菌群代谢产物短链脂肪酸的相关角色
10.1021/acs.jafc.0c04290
11-05, Article
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Antenatal obesity increases the risk of postpartum depression. Previous research found that dietary fiber supplementation could alleviate mental behavioral disorders. The present study aims to uncover the effects of high-dietary fiber intake on high-fat diet (HFD)-induced depressive-like behaviors and its underlying mechanism. Female C57BL6/J mice were fed with HFD to establish an antenatal obese model. A high-dietary fiber intake (inulin, 0.037 g/kcal) significantly attenuated cognitive deficits and depressive-like behaviors in the maternal mice after the offspring weaning. High-dietary fiber intake upregulated the expression of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) and suppressed neuroinflammation. Furthermore, high-dietary fiber intake restructured the gut microbiome and elevated the formation of short-chain fatty acids (SCFAs). Correlation analysis indicated that the increase in microbes such as Lactobacillus and S24-7, and SCFAs’ levels were positively correlated with behavioral improvements. In conclusion, high-dietary fiber intake is a promising nutritional intervention strategy to prevent antenatal obesity-induced behavioral disorders via a microbiota–gut–brain axis.
First Authors:
Zhigang Liu
Correspondence Authors:
Xuebo Liu
All Authors:
Zhigang Liu,Ling Li,Shaobo Ma,Jin Ye,Hongbo Zhang,Yitong Li,Ali Tahir Sair,Junru Pan,Xiaoning Liu,Xiang Li,Shikai Yan,Xuebo Liu