▲分子伴侣HSP70与DNAJB1、HSP110协同作用,识别并结合α突触核蛋白淀粉样蛋白原纤维,最终将其拆解(图片来源:参考资料[3];Credit: Bernd Bukau / Heidelberg University)Bukau教授总结说:“这两项研究的最新结果使我们对淀粉样蛋白原纤维如何溶解有了分子层面的理解。我们得以确信,分子伴侣可以像机器一样溶解原纤维。”研究人员相信,这一发现将开辟一条新的药物开发道路,通过特异性靶向基于分子伴侣的机制,达到消除蛋白聚集的目的,为干预神经退行性疾病的新疗法奠定基础。参考资料[1] Anne S. Wentink et al., (2020) Molecular dissection of amyloid disaggregation by human HSP70. Nature. Doi: https://doi.org/10.1038/s41586-020-2904-6[2] O. Faust, et al., (2020) Hsp40s employ class-specific regulation to drive Hsp70 functional diversity. Nature, Doi: 10.1038/s41586-020-2906-4[3] How molecular chaperones dissolve protein aggregates linked to Parkinson's disease. Retrieved Nov. 12, 2020, from https://www.uni-heidelberg.de/en/newsroom/how-molecular-chaperones-dissolve-protein-aggregates-linked-to-parkinsons-disease