益生菌对体重和体重指数的影响:随机对照试验系统回顾与荟萃分析
2016年8日,英国泰勒与弗朗西斯出版集团旗下《国际食品科学与营养杂志》第67卷第5期将正式发表泰州市人民医院的随机对照试验系统回顾与荟萃分析,发现摄入益生菌可减轻体重和体重指数。
益生菌对消化系统健康的益处已经得到广泛认可。益生菌补充剂经常被加入酸奶,可提高免疫力。然而,一直缺乏益生菌有益于体重和体重指数的证据。既往大量研究调查了益生菌对体重和体重指数的影响,但无一致结果。
该系统回顾与荟萃分析包括20项研究25项随机对照试验共1931位年龄>18岁的参与者,调查益生菌对体重和体重指数的影响。
结果发现,补充益生菌可使体重降低0.59kg(95%置信区间:0.30~0.87)、体重指数降低0.49kg/m²(95%置信区间:0.24~0.74)。亚组分析显示,摄入益生菌种类>1种或时间≥8周,体重指数降低更显著(P<0.01)。敏感性分析显示,超重(体重指数≥25kg/m²)者降幅最大(P<0.01)。
该系统回顾与荟萃分析最重要的发现是,根据25项随机对照试验,发现益生菌确实可致体重和体重指数下降,尤其对于摄入益生菌种类>1种或时间≥8周或超重者。
Int J Food Sci Nutr. 2016 Aug;67(5):571-80.
Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trials.
Zhang Q, Wu Y, Fei X.
Taizhou People's Hospital, Taizhou, China.
OBJECTIVE: To assess the efficacy of probiotic therapies on body weight and BMI using a meta-analysis of randomized, controlled trials.
METHODS: Twenty studies with 25 trials (1931 participants with age over 18 years) were included. The pooled WMD was calculated by random effects model.
RESULTS: Probiotic consumption significantly reduced body weight by 0.59 kg (95% CI, 0.30-0.87) and BMI by 0.49 kg/m(2) (95% CI, 0.24-0.74). A greater reduction in BMI was found with multiple species of probiotics. Subgroup analysis of trials with intervention duration ≥8 weeks found a more significant reduction in BMI. Limiting analysis to trials with a baseline BMI ≥25 kg/m(2) showed a greater reduction in BMI.
CONCLUSION: Consuming probiotics could reduce body weight and BMI, with a potentially greater effect when multiple species of probiotics were consumed, the duration of intervention was ≥8 weeks, or the objects were overweight.
KEYWORDS: BMI; meta-analysis; obesity; overweight; probiotics
PMID: 27149163
DOI: 10.1080/09637486.2016.1181156