铁证!NMN可以被细胞直接吸收!
Click on the blue text above follow GeneChic
NMN可以被细胞直接吸收
NMN can be directly absorbed by cells
烟酰胺腺嘌呤二核苷酸（NAD＋）
是维持细胞活力最重要的代谢物（没有之一）
随着年龄增长，NAD＋水平会不断下降
细胞活力进入下行通道并导致个体衰老
烟酰胺单核苷酸（NMN）是NAD+的直接前体
补充NMN可以有效提升NAD+
仔细观察NMN这个代谢物上
存在一个负电荷的磷酸集团
这种分子结构导致NMN不能有效通过细胞膜
那么问题来了
NMN怎么实现跨膜转运到细胞里的呢？
如果NMN不能有效进入细胞
那NMN生成NAD+的效果就要打折扣了
Nicotinamide adenine dinucleotide (NAD+) is the most important metabolite (no one) for maintaining cell viability. As people getting old, NAD+ levels will continue to decline and cell viability will enter the downward channel and lead to individual aging. Nicotinamide mononucleotide (NMN) is the direct precursor of NAD+. Supplementing NMN can effectively improve NAD+. There is a negatively charged phosphate group on the metabolite of NMN. This molecular structure prevents NMN from effectively passing through the cell membrane. So, the question is how does NMN achieve transmembrane transport into the cell? If NMN cannot effectively enter the cell, then the effect of NAD+ produced by NMN will be compromised.
来自美国华盛顿大学日裔科学家团队
Shin-ichiro Imai发现
一个细胞膜上的转运蛋白Slc12a8
这个蛋白帮助NMN跨膜进入细胞
Shin-ichiro Imai, a Japanese scientist from the University of Washington in the United States, discovered a transporter protein Slc12a8 on the cell membrane, which helps NMN enter the cell across the membrane.
科学家发现
|
01 ｜Slc12a8基因编码一个特定的NMN细胞膜转运蛋白，帮助NMN进入细胞 |
|
02 ｜Slc12a8特异性转运NMN，对其他前体如烟酰胺核苷酸（NR），烟酰胺（NAM）没有作用 |
|
03 ｜转运蛋白Slc12a8在小肠和胰腺中高度表达，在肝脏和白色脂肪组织中等表达 |
|
04 ｜衰老小鼠模型中，口服给药NMN，与年轻小鼠相比，老龄小鼠的血浆NMN水平升高的倍数更多，而且小肠中NAD+水平恢复到接近年轻小鼠的水平 |
Scientists found that:
1. The Slc12a8 gene encodes a specific NMN cell membrane transporter protein, which helps NMN enter the cell;
2. Slc12a8 specifically transports NMN and has no effect on other precursors such as nicotinamide nucleotide (NR) and nicotinamide (NAM);
3. The transporter Slc12a8 is highly expressed in the small intestine and pancreas, and moderately expressed in the liver and white adipose tissue;
4. In the aging mouse model, oral administration of NMN, compared with young mice, will cause the plasma NMN level of old mice increased by more times, and the NAD+ level in the small intestine returned to the level close to that of young mice;
至此，这个链条终于实现闭环且环环相扣
口服补充NMN转运蛋白Slc12a8
特异性帮助NMN进入细胞NMN
在细胞高效生成NAD+NAD+激活细胞
代谢水平实现细胞组织个体年轻化
At this point, this chain has finally formed a circle. Oral supplementation of NMNè transporter protein Slc12a8 specifically helps NMN enter the cell, andèNMN efficiently produces NAD+ in the cell which activates the cell metabolism levelè realizes the rejuvenation of individual cell tissues.