Science：从海洋菌群挖掘新型抗真菌药 | 热心肠日报

A marine microbiome antifungal targets urgent-threat drug-resistant fungi

一种海洋微生物组抗真菌物质靶向具有急迫威胁的耐药真菌

10.1126/science.abd6919

11-20, Article

Abstract & Authors:展开

Abstract:收起
New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug–resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as C. auris.

First Authors:
Fan Zhang,Miao Zhao

Correspondence Authors:
David R Andes,Tim S Bugni

All Authors:
Fan Zhang,Miao Zhao,Doug R Braun,Spencer S Ericksen,Jeff S Piotrowski,Justin Nelson,Jian Peng,Gene E Ananiev,Shaurya Chanana,Kenneth Barns,Jen Fossen,Hiram Sanchez,Marc G Chevrette,Ilia A Guzei,Changgui Zhao,Le Guo,Weiping Tang,Cameron R Currie,Scott R Rajski,Anjon Audhya,David R Andes,Tim S Bugni