Nature Reviews：早发性大肠癌知多少（综述） | 热心肠日报
Rising incidence of early-onset colorectal cancer — a call to action
早发性结直肠癌发病率上升——行动倡议
10.1038/s41571-020-00445-1
11-20, Article
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The incidence of early-onset colorectal cancer (CRC), which occurs in individuals <50 years of age, has been increasing worldwide and particularly in high-income countries. The reasons for this increase remain unknown but plausible hypotheses include greater exposure to potential risk factors, such as a Western-style diet, obesity, physical inactivity and antibiotic use, especially during the early prenatal to adolescent periods of life. These exposures can not only cause genetic and epigenetic alterations in colorectal epithelial cells but also affect the gut microbiota and host immunity. Early-onset CRCs have differential clinical, pathological and molecular features compared with later-onset CRCs. Certain existing resources can be utilized to elucidate the aetiology of early-onset CRC and inform the development of effective prevention, early detection and therapeutic strategies; however, additional life-course cohort studies spanning childhood and young adulthood, integrated with prospective biospecimen collections, omics biomarker analyses and a molecular pathological epidemiology approach, are needed to better understand and manage this disease entity. In this Perspective, we summarize our current understanding of early-onset CRC and discuss how we should strategize future research to improve its prevention and clinical management.
First Authors:
Naohiko Akimoto,Tomotaka Ugai,Rong Zhong
Correspondence Authors:
Yin Cao,Kimmie Ng,Shuji Ogino
All Authors:
Naohiko Akimoto,Tomotaka Ugai,Rong Zhong,Tsuyoshi Hamada,Kenji Fujiyoshi,Marios Giannakis,Kana Wu,Yin Cao,Kimmie Ng,Shuji Ogino