【Meta分析】PROSPERO注册详细步骤与示例
系统评价/Meta分析指全面收集所有相关研究并逐个进行严格评价和分析,再用定性或定量合成的方法对资料进行处理得出综合结论的研究方法。在指导学员的过程中发现初学者在学习过程中常常会碰到许多共性问题,本公众号特此开设专栏解答,希望能够和大家共同学习交流Meta分析,共同成长,如有不当之处,还请大家批评指正。本期我们将着重介绍Meta分析的注册流程。
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序言
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注册账号
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注册实例
例如: 1. A systematic review and meta-analysis of rehabilitation in patients with sepsis(体现PI)
A network meta-analysis of interventions to control myopia progression in children(体现PO) Minocycline in depressive symptoms: a meta-analysis of randomized controlled trials(体现PIS)
通常表明该研究的目的,可以是以问句或者陈述句的形式,例如
干预性meta分析:The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and safety of adjunctive minocycline for depressive symptoms regardless of the main psychiatric condition. Whether could IgA nephropathy patients benefit from omega-3 fatty acids treatment? How do the kidney function and daily proteinuria of IgA nephropathy patients change after taking omega-3 fatty acids comparing with placebos? 率的meta分析:What is the prevalence of neuropathic pain in patients with symptomatic knee osteoarthritis? 也可以自问自答:What are the effects of the various optical, pharmacological and lifestyle interventions in preventing myopia progression in children? We aim to generate a clinically useful summary of the interventions based on their efficacy.
这部分内容中不需要给出完善的检索策略(可作为附件上传),主要描述检索的方式以及检索词的关键词,例如:
We will search, with no time restrictions, the following databases for relevant English language literature: PubMed (MEDLINE), the Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science.The search string will be built as follows: 可替换(Osteoarthritis OR OA) AND (pain) AND (neuropathic OR nociceptive OR central sensitization OR DN4 OR painDETECT OR S-LANSS OR quantitative sensory testing). The electronic database search will be supplemented by a manual search of the reference lists of included articles. We will search articles in three electronic database including PubMed, EMBASE and Cochrane Library. All the English publications until 30 April 2018 will be searched without any restriction of countries or article type. Reference list of all selected articles will independently screened to identify additional studies left out in the initial search.
可上传完整检索策略的PDF文档,上传后则默认可以公开访问,整理的格式以不#1、#2、#3的形式,具体可以参加课程。
相当于是论文背景部分的简化版,一般包括疾病的概述以及流行病学数据、干预措施的研究现状与不足等信息 如:
Supracondylar humeral fracture(SCHF) is the extremely common pediatric fracture in children younger than 15 years, accounting for approximately 75% of all pediatric elbow injuries. It has been suggested that 96% of all SCHFs are extension-type injuries that occur during falls onto the outstretched hand, whereas between 1% and 2% occur through falls onto the olecranon with the elbow flexed. Supracondylar fractures, most commonly, are classified according to Gartland ’s criteria: types I (nondisplaced and stable), type II (hinged fractures with the posterior cortex intact), and type III (completely displaced). Depression in adults, and its treatment using cognitive remediation therapy.Cognitive remediation therapy is the general term for a kind of psychotherapy which focuses on correcting and changing patients' adaptations to benign cognition. Its main goal is the remediation of bad cognition, but the patient's emotions and the behavior can also be changed.
主要描述P,如Adults with depression (as diagnosed by a clinician, or using any recognized diagnostic criteria) will be included. 但在这里需要指出的是排除标准一定是在纳入标准的范围里面再进行排除,不能出现下述表达如纳入小于18岁,排除18岁以上(即使注册成功也错误多多,主要原因是没有规范的掌握方法学)
这一部分主要描述I,可简单也可复杂,但是尽量能够贴近成稿论文 Physical exercise was the main intervention (e.g. aerobic exercise, resistance exercise and multicomponent exercise program).
相对于干预措施,主要描述对照措施
一般情况下我们纳入随机对照试验,则可以表述为Randomized controlled trials (RCTs) will be included.这一部分也可以对发表时间、语言类型等做限制如Randomized clinical trials will be included irrespective of blinding, publication status or language.,但不建议对P或者I做更多的描述
简略写一下名称,如overall survival (OS) and progression-free survival (PFS).或者某个量表的变化如mean change in WOMAC pain,需要结合自己的研究进行判断
描述结局指标的效应量,如二分类变量选择RR/OR, 连续性变量选择SMD/MD, 生存分析资料选HR
与主要结局指标方法相同,主要填写系统评价的次要结局指标
一般有模版,先表示两人独立提取,第三人解决分歧如Two authors will independently extract data. Any disagreement will be resolved by discussion until consensus is reached or by consulting a third author.同时最好加上需要提取哪些信息,如The following data will be extracted: author, year of publication, country where the study was conducted, study period, original inclusion criteria, total number of people included in the study, doses of progesterone and time of application, and mean cervical length.
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