trypsin-2 isoform 2 preproprotein [Homo sapiens]

Go to:

LOCUS       NP_002761                247 aa            linear   PRI 20-FEB-2021DEFINITION  trypsin-2 isoform 2 preproprotein [Homo sapiens].ACCESSION   NP_002761 XP_003846777 XP_003960991VERSION     NP_002761.1DBSOURCE    REFSEQ: accession NM_002770.4KEYWORDS    RefSeq; MANE Select.SOURCE      Homo sapiens (human)  ORGANISM  Homo sapiens            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;            Catarrhini; Hominidae; Homo.REFERENCE   1  (residues 1 to 247)  AUTHORS   Polonikov AV, Samgina TA, Nazarenko PM, Bushueva OY and Ivanov VP.  TITLE     Alcohol Consumption and Cigarette Smoking are Important Modifiers            of the Association Between Acute Pancreatitis and the PRSS1-PRSS2            Locus in Men  JOURNAL   Pancreas 46 (2), 230-236 (2017)   PUBMED   27846138  REMARK    GeneRIF: Data indicate association between polymorphism rs10273639            of the PRSS1-PRSS2 locus and pancreatitis development.REFERENCE   2  (residues 1 to 247)  AUTHORS   Avanthi SU, Ravi Kanth VV, Agarwal J, Lakhtakia S, Gangineni K, Rao            GV, Reddy DN and Talukdar R.  TITLE     Association of claudin2 and PRSS1-PRSS2 polymorphisms with            idiopathic recurrent acute and chronic pancreatitis: A case-control            study from India  JOURNAL   J Gastroenterol Hepatol 30 (12), 1796-1801 (2015)   PUBMED   26110235  REMARK    GeneRIF: evaluated the association of claudin2 and PRSS1-PRSS2            polymorphisms with idiopathic recurrent acute (RAP) and chronic            pancreatitisREFERENCE   3  (residues 1 to 247)  AUTHORS   Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C,            Lichtner P, Te Morsche RH, Cavestro GM, Ferec C, Drenth JP, Witt H            and Rosendahl J.  CONSRTM   PanEuropean Working group on Alcoholic Chronic Pancreatitis Members            and Collaborators  TITLE     Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with            alcoholic and non-alcoholic chronic pancreatitis in a European            replication study  JOURNAL   Gut 64 (9), 1426-1433 (2015)   PUBMED   25253127  REMARK    GeneRIF: PRSS2 single nucleotide polymorphism associated with the            development of alcoholic pancreatitis.REFERENCE   4  (residues 1 to 247)  AUTHORS   Cao,J., Xia,C., Cui,T., Guo,H., Li,H., Ren,Y. and Wang,S.  TITLE     Correlations between serum trypsinogen-2 and pancreatic cancer  JOURNAL   Hepatogastroenterology 62 (138), 435-440 (2015)   PUBMED   25916077  REMARK    GeneRIF: Serum trypsinogen-2 is associated with pancreatic cancer            and pancreatitis.REFERENCE   5  (residues 1 to 247)  AUTHORS   Rowen L, Koop BF and Hood L.  TITLE     The complete 685-kilobase DNA sequence of the human beta T cell            receptor locus  JOURNAL   Science 272 (5269), 1755-1762 (1996)   PUBMED   8650574REFERENCE   6  (residues 1 to 247)  AUTHORS   Belorgey D, Dirrig S, Amouric M, Figarella C and Bieth JG.  TITLE     Inhibition of human pancreatic proteinases by mucus proteinase            inhibitor, eglin c and aprotinin  JOURNAL   Biochem J 313 (Pt 2), 555-560 (1996)   PUBMED   8573092REFERENCE   7  (residues 1 to 247)  AUTHORS   Vercaigne-Marko D, Carrere J, Guy-Crotte O, Figarella C and Hayem            A.  TITLE     Human cationic and anionic trypsins: differences of interaction            with alpha 1-proteinase inhibitor  JOURNAL   Biol Chem Hoppe Seyler 370 (11), 1163-1171 (1989)   PUBMED   2610933REFERENCE   8  (residues 1 to 247)  AUTHORS   Kimland M, Russick C, Marks WH and Borgstrom A.  TITLE     Immunoreactive anionic and cationic trypsin in human serum  JOURNAL   Clin Chim Acta 184 (1), 31-46 (1989)   PUBMED   2598466REFERENCE   9  (residues 1 to 247)  AUTHORS   Emi,M., Nakamura,Y., Ogawa,M., Yamamoto,T., Nishide,T., Mori,T. and            Matsubara,K.  TITLE     Cloning, characterization and nucleotide sequences of two cDNAs            encoding human pancreatic trypsinogens  JOURNAL   Gene 41 (2-3), 305-310 (1986)   PUBMED   3011602REFERENCE   10 (residues 1 to 247)  AUTHORS   Figarella,C., Negri,G.A. and Guy,O.  TITLE     The two human trypsinogens. Inhibition spectra of the two human            trypsins derived from their purified zymogens  JOURNAL   Eur J Biochem 53 (2), 457-463 (1975)   PUBMED   1079768COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The            reference sequence was derived from BC005814.2, BC030260.1,            AC245427.3 and CA867206.1.            This sequence is a reference standard in the RefSeqGene project.            On or before Aug 31, 2013 this sequence version replaced            XP_003960991.1, XP_003846775.1, XP_003846776.1, XP_003846777.1.                        Summary: This gene belongs to the trypsin family of serine            proteases and encodes anionic trypsinogen. It is part of a cluster            of trypsinogen genes that are located within the T cell receptor            beta locus. Enzymes of this family cleave peptide bonds that follow            lysine or arginine residues. This protein is found at high levels            in pancreatic juice and its upregulation is a characteristic            feature of pancreatitis. This protein has also been found to            activate pro-urokinase in ovarian tumors, suggesting a function in            tumor invasion. In addition, this enzyme is able to cleave across            the type II collagen triple helix in rheumatoid arthritis synovitis            tissue, potentially participating in the degradation of type II            collagen-rich cartilage matrix. Alternative splicing results in            multiple transcript variants.[provided by RefSeq, Jan 2015].                        Transcript Variant: This variant (2) lacks an in-frame exon            compared to variant 1. The encoded isoform (2) is shorter than            isoform 1.                        Publication Note:  This RefSeq record includes a subset of the            publications that are available for this gene. Please see the Gene            record to access additional publications.                        ##Evidence-Data-START##            Transcript exon combination :: CA772699.1, CA776091.1 [ECO:0000332]            RNAseq introns              :: single sample supports all introns                                           SAMEA1965299, SAMEA1968189                                           [ECO:0000348]            ##Evidence-Data-END##                        ##RefSeq-Attributes-START##            MANE Ensembl match     :: ENST00000539842.6/ ENSP00000488338.1            RefSeq Select criteria :: based on conservation, expression            ##RefSeq-Attributes-END##FEATURES             Location/Qualifiers     source          1..247                     /organism="Homo sapiens"                     /db_xref="taxon:9606"                     /chromosome="7"                     /map="7q34"     Protein         1..247                     /product="trypsin-2 isoform 2 preproprotein"                     /EC_number="3.4.21.4"                     /note="trypsinogen 2; anionic trypsinogen; trypsin II;                     trypsin-2; protease serine 2 preproprotein; protease,                     serine, 2 (trypsin 2); protease, serine 2"                     /calculated_mol_wt=24946     sig_peptide     1..15                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"                     /calculated_mol_wt=1560     proprotein      16..247                     /product="trypsin-2 isoform 2 proprotein"                     /calculated_mol_wt=24946     Region          23..239                     /region_name="Tryp_SPc"                     /note="Trypsin-like serine protease; smart00020"                     /db_xref="CDD:214473"     mat_peptide     24..247                     /product="Trypsin-2. /id=PRO_0000028200"                     /note="propagated from UniProtKB/Swiss-Prot (P07478.1)"                     /calculated_mol_wt=24042     Region          24..242                     /region_name="Tryp_SPc"                     /note="Trypsin-like serine protease; Many of these are                     synthesized as inactive precursor zymogens that are                     cleaved during limited proteolysis to generate their                     active forms. Alignment contains also inactive enzymes                     that have substitutions of the catalytic triad...;                     cd00190"                     /db_xref="CDD:238113"     Site            24                     /site_type="cleavage"                     /db_xref="CDD:238113"     Site            order(63,107,200)                     /site_type="active"                     /db_xref="CDD:238113"     Site            154                     /site_type="sulfatation"                     /note="Sulfotyrosine.                     /evidence=ECO:0000305|PubMed:17087724,                     ECO:0000305|PubMed:25010489; propagated from                     UniProtKB/Swiss-Prot (P07478.1)"     Site            order(194,215,217)                     /site_type="other"                     /note="substrate binding sites [chemical binding]"                     /db_xref="CDD:238113"     Site            194                     /site_type="other"                     /note="Required for specificity. /evidence=ECO:0000250;                     propagated from UniProtKB/Swiss-Prot (P07478.1)"     CDS             1..247                     /gene="PRSS2"                     /gene_synonym="TRY2; TRY8; TRYP2"                     /coded_by="NM_002770.4:14..757"                     /note="isoform 2 preproprotein is encoded by transcript                     variant 2"                     /db_xref="CCDS:CCDS83236.1"                     /db_xref="GeneID:5645"                     /db_xref="HGNC:HGNC:9483"                     /db_xref="MIM:601564"ORIGIN              1 mnllliltfv aaavaapfdd ddkivggyic eensvpyqvs lnsgyhfcgg sliseqwvvs       61 aghcyksriq vrlgehniev legneqfina akiirhpkyn srtldndill iklsspavin      121 srvsaislpt appaagtesl isgwgntlss gadypdelqc ldapvlsqae ceasypgkit      181 nnmfcvgfle ggkdscqgds ggpvvsngel qgivswgygc aqknrpgvyt kvynyvdwik      241 dtiaans//