华盛顿大学医学院临床二期试验：首次证实补充NMN改善糖尿病患者胰岛素敏感性

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原文链接

https://science.sciencemag.org/lookup/doi/10.1126/science.abe9985.DOI: 10.1126/science.abe9985 (2021)

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参考文献

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  2. E. Katsyuba, M. Romani, D. Hofer, J. Auwerx, NAD+ homeostasis in health and disease. Nat Metab 2, 9–31 (2020).

  3. J. Yoshino, K. F. Mills, M. J. Yoon, S. Imai, Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 14, 528–536 (2011).

  4. M. Razmara, C. H. Heldin, J. Lennartsson, Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D. Cell Commun. Signal. 11, 3 (2013).

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