Hegedus吲哚合成反应

化学当量的Pd(II)催化剂氧化环化链烯基苯胺得到吲哚的反应。反应机理和Wacker氧化类似。

反应机理

反应实例

参考文献

1. (a) Hegedus, L. S.; Allen, G. F.; Waterman, E. L. J. Am. Chem. Soc. 1976, 98,

2674-􀀐2676. Lou Hegedus is a professor at Colorado State University. (b) Hegedus, L. S.; Allen, G. F.; Bozell, J. J.; Waterman, E. L. J. Am. Chem. Soc. 1978, 100, 5800-􀀐5807. (c) Hegedus, L. S.; Winton, P. M.; Varaprath, S. J. Org. Chem. 1981, 46,2215􀀐-2221. (d) Harrington, P. J.; Hegedus, L. S. J. Org. Chem. 1984, 49, 2657-􀀐2662.

(e) Hegedus, L. S. Angew. Chem. Int. Ed. 1988, 27, 1113-􀀐1126. (Review).

2. Brenner, M.; Mayer, G.; Terpin, A.; Steglich, W. Chem. Eur. J. 1997, 3, 70􀀐-74.

3. Osanai, Y. Y.; Kondo, K.; Murakami, Y. Chem. Pharm. Bull. 1999, 47, 1587-􀀐1590.

4. Kondo, T.; Okada, T.; Mitsudo, T. J. Am. Chem. Soc. 2002, 124, 186-􀀐187. A ruthenium variant.

5. Johnston, J. N. Hegedus Indole Synthesis. In Name Reactions in Heterocyclic Chemistry; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2005, pp 135􀀐-139. (Review).

编译自：J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, Hegedus indole synthesis，page309.