地佐辛在预防异丙酚注射痛中的作用：Meta分析
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Effects of dezocine on prevention of propofol injection pain: a meta-analysis
背景与目的
本研究的目的是评价地佐辛在预防异丙酚注射痛中的作用。
方 法
我们通过在PubMed，Embase，Cochrane图书馆和CNKI上搜索了截止到到2016年4月的有关地佐辛预防异丙酚注射痛的随机对照试验（RCTs）。 然后两位评审人员根据纳入和排除标准独立筛选文献，提取数据并评估质量。 最后，使用RevMan5.2软件进行Meta分析。
结 果
该Meta分析纳入了七个随机对照试验，共计630例患者。其研究结果表明：1）与对照组相比（相对危险度[RR] = 0.32，95% CI [ 0.26,0.39 ]，P＜0.00001），地佐辛组异丙酚注射痛的发生率降低；2）就异丙酚注射痛的严重程度而言，地佐辛组与对照组相比，轻度疼痛发生率（RR = 0.55，95% CI [ 0.40,0.75 ]，P = 0.0001），中度疼痛发生率（RR = 0.28，95% CI [ 0.18，0.43 ]，P＜0.00001），重度疼痛发生率（RR = 0.11，95% CI [ 0.06，0.23 ]，P＜0.00001）明显降低；3）地佐辛组与利多卡因组相比，异丙酚注射痛的发生率差异无统计学意义（RR = 0.86，95% CI [ 0.66，1.13 ]，P = 0.29）；和4）亚组分析表明，异丙酚注射痛的发生率明显降低。
结 论
地佐辛既能预防异丙酚注射痛，同时也能降低其疼痛的严重程度，其有效性与利多卡因相比无显著差异。
原始文献摘要
Zhou C, Yang Y, Zhu Y, Ruan L. Effects of dezocine on prevention of propofol injection pain: a meta-analysis. J Pain Res. 2017 Jun 1;10:1369-1375. doi: 10.2147/JPR.S128889. eCollection 2017.
Objective: The objective of this study was to evaluate the effects of dezocine on the prevention of propofol injection pain.
Materials and methods: We searched for randomized controlled trials (RCTs) of dezocine in preventing propofol injection pain, from inception to April 2016, in PubMed, Embase, Cochrane Library, and CNKI. Next, two reviewers independently screened literature, extracted data, and assessed quality in accordance with the inclusion and exclusion criteria. Finally, RevMan 5.2 software was used to conduct a meta-analysis.
Results: Seven RCTs totaling 630 patients were included in this meta-analysis. The meta-analysis study showed: 1) compared with the control group (relative risk [RR] =0.32, 95% CI [0.26,0.39], P<0.00001), the dezocine group showed a decreasing incidence of propofol injection pain; 2) for severity of propofol injection pain, incidences of mild pain (RR =0.55, 95% CI [0.40,0.75], P=0.0001), moderate pain (RR =0.28, 95% CI [0.18, 0.43], P<0.00001), and severe pain(RR =0.11, 95% CI [0.06, 0.23], P<0.00001) were considerably lower in the dezocine group than in the control group; 3) when comparing the incidence of propofol injection pain in the dezocine group with that of the lidocaine group, no statistically significant differences were found (RR =0.86, 95% CI [0.66, 1.13], P=0.29); and 4) subgroup analysis indicated a significant
reduction in the incidence of propofol injection.
Conclusion: Dezocine can both prevent propofol injection pain and mitigate its severity, and its efficacy shows no significant difference from that of lidocaine.
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