368.Idiopathic pulmonary fibrosis

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Idiopathic pulmonary fibrosis

A disease of unknown etiology, usually occurring in older men who develop cough and shortness of breath.

The early stage is a milder form known as desquamative interstitial pneumonia (DIP) and its findings are usually seen best on high-resolution CT scans of the chest.

Later in the disease, it is called usual interstitial pneumonia (UIP), and there is marked thickening of the interstitium, bronchiectasis, and a pattern of cystic changes in the lung called honeycombing.

UIP is also best demonstrated on high-resolution CT scans of the chest.

Conventional radiographs of the chest may show a fine or, later in the disease, a coarse reticular pattern that is bilaterally symmetrical, most prominent at the bases, subpleural in location and frequently associated with volume loss.

Idiopathic pulmonary fibrosis is considered the end-stage disease along the spectrum of these interstitial pneumonias (Fig. 3-12).

Figure 3-12 Idiopathic pulmonary fibrosis. Idiopathic pulmonary fibrosis probably represents a spectrum of disease that may begin as desquamative interstitial pneumonia (DIP) and lead to the findings here of usual interstitial pneumonia (UIP). A, coarse reticular interstitial markings represent fibrosis, predominantly at the lung bases (black circles). B, A high-resolution CT scan of the chest shows abnormalities at the lung bases in a subpleural location, the typical distribution for UIP. There are small cystic spaces called honeycombing (black circles) with hazy densities called ground-glass opacities (solid white arrows).

Notes:

1. desquamative /di'skwæmətivdi'skwæmətiv/ adj. 脱屑的,脱皮的

2. interstitial /ˌɪntɚ'stɪʃl/ adj. 空隙的,裂缝的,形成空隙的

3. bronchiectasis /ˌbrɑŋkɪ'ɛktəsɪs/ n. 支气管扩张

4. subpleural /sʌb'pluərəl/ adj. 胸膜下的

来源：每天朗读一段医学影像学英语文章

圈主

深圳市人民医院放射科副主任医师杨敏洁

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