哈尔滨医科大学：等热量中等高脂饮食或能延长寿命 | 热心肠日报
An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila
等热量的中等高脂饮食可延长雄性大鼠和果蝇的寿命
10.1016/j.cmet.2020.12.017
01-12, Article
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The health effect of dietary fat has been one of the most vexing issues in the field of nutrition. Few animal studies have examined the impact of high-fat diets on lifespan by controlling energy intake. In this study, we found that compared to a normal diet, an isocaloric moderately high-fat diet (IHF) significantly prolonged lifespan by decreasing the profiles of free fatty acids (FFAs) in serum and multiple tissues via downregulating FFA anabolism and upregulating catabolism pathways in rats and flies. Proteomics analysis in rats identified PPRC1 as a key protein that was significantly upregulated by nearly 2-fold by IHF, and among the FFAs, only palmitic acid (PA) was robustly and negatively associated with the expression of PPRC1. Using PPRC1 transgenic RNAi/overexpression flies and in vitro experiments, we demonstrated that IHF significantly reduced PA, which could upregulate PPRC1 through PPARG, resulting in improvements in oxidative stress and inflammation and prolonging the lifespan.
First Authors:
Dan Shi,Tianshu Han
Correspondence Authors:
YuCun Niu,Ying Li,Changhao Sun
All Authors:
Dan Shi,Tianshu Han,Xia Chu,Huimin Lu,Xue Yang,TianQi Zi,YanHe Zhao,XinYue Wang,ZhiPeng Liu,JingQi Ruan,Xin Liu,Hua Ning,MaoQing Wang,Zhen Tian,Wei Wei,Yue Sun,YinLing Li,Rui Guo,Yu Wang,Fan Ling,Yue Guan,Da Shen,YuCun Niu,Ying Li,Changhao Sun