「NR」Curtius rearrangement——异氰酸酯的制备
定义
叠氮酰基化合物的热分解(热解)得到相应的异氰酸酯,称为Curtius rearrangement(库尔修斯重排)
反应通式
起源与发展
反应的一般特征
机理
反应实例
1) Synthesis of 3-Aryl-2-arylamidobenzofurans Based on the Curtius Rearrangement
DOI: 10.1021/jo102265b
2) The Curtius Rearrangement of Cyclopropyl and Cyclopropenoyl Azides. A Combined Theoretical and Experimental Mechanistic Study
DOI: 10.1021/jo801104t
3) Pyridone Annulation via Tandem Curtius Rearrangement/6π-Electrocyclization: Total Synthesis of (−)-Lyconadin C
DOI: 10.1021/ol401954f
4) Contrasting Photolytic and Thermal Decomposition of Phenyl Azidoformate: The Curtius Rearrangement Versus Intramolecular C–H Amination
DOI: 10.1021/acs.jpca.7b07969
5) Use of a Curtius Rearrangement as Part of the Multikilogram Manufacture of a Pyrazine Building Block
DOI: 10.1021/acs.oprd.7b00340
6) The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry
https://doi.org/10.1002/cmdc.201800518
7) Photoinduced, Copper-Catalyzed Decarboxylative C–N Coupling to Generate Protected Amines: An Alternative to the Curtius Rearrangement
DOI: 10.1021/jacs.7b07546
评述
参考