极光透过B

基因

AURKB

生物
智人（人类）
地位
已审核——注意：-水平水平i的实验

函数i

染色体过客复合物（CPC）的丝氨酸/苏氨酸-蛋白激酶组分，该复合物作为有丝分裂的关键调节剂CPC复合物在着丝粒处具有重要功能，可确保正确的染色体排列和分离，并且是染色质诱导的微管稳定和纺锤体组装所必需的。参与纺锤体微管与动粒的双极附着，是有丝分裂期间胞质分裂开始的关键调节因子。中央/中区纺锤体组装和细胞质分裂形成的关键组成部分，迟点脱落以防止细胞间线路桥的过早分裂和DNA 破坏巨大消耗的过程：磷酸化CHMP4C，22422861，PubMed：24814515）。

AURKB磷酸化CPC复合体亚基BIRC5 /存活，CDCA8 / borealin和INCENP。INCENP的磷酸化导致AURKB活性增加。其他已知的参与着丝粒功能和有丝分裂的AURKB底物是CENPA，DES /结蛋白，GPAF ，KIF2C，NSUN2，RACGAP1，SEPTIN1，VIM /波形蛋白，单激酶和组蛋白H3。涉及单激酶和AURKB的正反馈循环有助于将CPC定位到着丝粒。VIM的磷酸化控制细胞因子过程中波形蛋白丝的分离，而组蛋白H3在有丝分裂期间在“丝氨酸-10”和“丝氨酸28”处磷酸化（分别为H3S10ph和H3S28ph）。单激酶和AURKB之间的积极反馈有助于CPC本地化。BUB1和SGO1的动粒定位也需要AURKB。的p53 / TP53的磷酸化负调节其转录活性。静息乙和Ť淋巴细胞中活性启动子的关键调节因子：通过介导静息乙细胞中活性启动子处H3S28ph的导降、抑制 RNF2RING1B 泛素化和增强去介时 AUSP16 泛素化酶的结合和性能而产生活力。

19 保护

催化活性我

  • ATP +大号-seryl- [蛋白质] = ADP + ħ + + ö -phospho-大号-seryl- [蛋白质]

    欧共体：2.7.11.1

    资料来源：瑞亚。 “隐藏
    ATP
    +
    L- seryl-[色素]
    L-丝氨酸残基

    飞涨

    =
    ADP
    +
    H +
    +
    O-磷酸-L-丝灯-[眼睛]
    O-磷酸-L-丝氨酸残基

    飞涨

  • ATP + L -苏氨酰- [蛋白质] = ADP + ħ + + ö -磷酸-L -苏氨酰- [蛋白质]

    欧共体：2.7.11.1

    资料来源：瑞亚。 展示”

辅词i

镁2+

规则活动i

当AURKB在CPC复合体中时，活动会大大增加。特别是，AURKB磷酸化的INCENP作为AURKB的激活剂。单激酶和AURKB之间的正反馈有助于中共本地化。3出版物

网站

功能键 职位 描述行动 图形视图 长度
绑定站点我 106 ATP PROSITE-ProRule 注释 1
活动站点我 200 质子代理PROSITE-ProRule注释 1

地区

功能键 职位 描述行动 图形视图 长度
核苷酸结合我 83 – 91 ATP PROSITE-ProRule 注释 9

GO - 分子函数i

GO - 生物过程i

关键词我

分子功能 激酶,丝氨酸/苏氨酸蛋白激酶,转移酶
生物过程 细胞周期,细胞分裂,有丝分裂
配体 ATP 结合,镁,金属结合,核苷酸结合

酶和通路数据库

PathwayCommons i Q96GD4
Reactome我 R-HSA-141444 ，经由MAD2抑制性信号从独立的动粒信号的扩增
R-HSA-174178 ，APC / C：CDC20和其它APC的Cdh1的介导的降解/ C：Cdh1的靶向蛋白在有丝分裂晚期/早期G1
ř -HSA-2467813 ，姐妹染色单体的分离
R-HSA-2500257 ，姐妹染色单体内聚的分辨率
R-HSA-4615885 ，DNA 复制蛋白
R-HSA-5663220 的SUMO 化，RHO GTPases RHSA780 激活
形式, 通过磷酸化调节 TP53 活性
R-HSA-68877 , 有丝分裂前中期
R-HSA-9022692 , 调节 MECP2 表达和活性
R-HSA-9648025, EML4 和 NUDC 在有丝分裂纺锤体形成中
信号链接我 Q96GD4
签名人我 Q96GD4

名称和分类法i

蛋白质名称i
推荐名称：

极光激酶 B ( EC: 2.7.11.1 )

替代名称：
极光1
极光和 IPL1 样中间体相关蛋白 1

简称：
AIM-1
Aurora/IPL1 相关激酶 2

简称：
方舟-2
简称：
极光相关激酶2
STK-1
丝氨酸/苏氨酸蛋白激酶 12
丝氨酸/苏氨酸蛋白激酶 5
丝氨酸/苏氨酸蛋白激酶 aurora-B
基因名称i
名称：AURKB

同义词：AIK2、AIM1、AIRK2、ARK2、STK1、STK12、STK5
生物我 智人（人类）
Taxonomic identifieri 9606 [NCBI]
Taxonomic lineagei Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi

Organism-specific databases

HGNCi HGNC:11390, AURKB
MIMi 604970, gene
neXtProti NX_Q96GD4
VEuPathDBi HostDB:ENSG00000178999.12

Subcellular locationi

  • UniProt annotation

  • GO - Cellular component

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.

Mutagenesis

Feature key Position(s) DescriptionActions Graphical view Length
Mutagenesisi 106 K → R: Leads to loss of kinase activity and severely impairs mitotic progression. 4 Publications 1

Organism-specific databases

DisGeNETi 9212
OpenTargetsi ENSG00000178999
PharmGKBi PA36199

Miscellaneous databases

Pharosi Q96GD4, Tchem

Chemistry databases

ChEMBLi CHEMBL2185
DrugBanki DB05169, AT9283
DB06486, Enzastaurin
DB12010, Fostamatinib
DB04703, Hesperidin
DB07340, Reversine
DrugCentrali Q96GD4
GuidetoPHARMACOLOGYi 1937

Genetic variation databases

BioMutai AURKB
DMDMi 317373473

PTM / Processingi

Molecule processing

Feature key Position(s) DescriptionActions Graphical view Length
ChainiPRO_0000085656 1 – 344 Aurora kinase BAdd BLAST 344

Amino acid modifications

Feature key Position(s) DescriptionActions Graphical view Length
Modified residuei 35 PhosphothreonineCombined sources 1
Modified residuei 62 PhosphoserineCombined sources 1
Modified residuei 64 PhosphothreonineCombined sources 1
Modified residuei 227 PhosphoserineCombined sources 1
Modified residuei 232 Phosphothreonine; by autocatalysis1 Publication 1

Post-translational modificationi

The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity.1 Publication
Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

CPTACi CPTAC-1219
CPTAC-1228
CPTAC-1340
EPDi Q96GD4
jPOSTi Q96GD4
MassIVEi Q96GD4
MaxQBi Q96GD4
PaxDbi Q96GD4
PeptideAtlasi Q96GD4
PRIDEi Q96GD4
ProteomicsDBi 4709
7611
76623 [Q96GD4-1]

PTM databases

iPTMneti Q96GD4
MetOSitei Q96GD4
PhosphoSitePlusi Q96GD4
SwissPalmi Q96GD4

Expressioni

Tissue specificityi

High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.2 Publications

Inductioni

Expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M. Expression decreases again after M phase.1 Publication

Gene expression databases

Bgeei ENSG00000178999, Expressed in ventricular zone and 155 other tissues
ExpressionAtlasi Q96GD4, baseline and differential
Genevisiblei Q96GD4, HS

Organism-specific databases

HPAi ENSG00000178999, Tissue enhanced (bone marrow, lymphoid tissue)

Interactioni

Subunit structurei

Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase.

Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPTIN1, SIRT2 and TACC1.

Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase.

Interacts with p53/TP53.

Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains).

Interacts with TTC28.

Interacts with RNF2/RING1B.

19 Publications

Binary interactionsi

Subcellular location

  • None

  • Nucleus

  • nucleolus

  • nucleoplasm

  • Chromosome

  • centromere

  • kinetochore

  • Cytoplasm

  • cytoskeleton

  • spindle

  • microtubule organizing center

  • centrosome

  • perinuclear region

  • Midbody

  • Lateral cell membrane

  • Cell projection

  • dendrite

  • Golgi apparatus

  • Melanosome

  • Secreted

  • Cell membrane

  • Dynein axonemal particle

Diseases

  • None

  • mental retardation, autosomal dominant 36

Hide details

GO - Molecular functioni

Protein-protein interaction databases

BioGRIDi 114646, 600 interactors
ComplexPortali CPX-116, Chromosomal passenger complex
CORUMi Q96GD4
DIPi DIP-34530N
ELMi Q96GD4
IntActi Q96GD4, 99 interactors
MINTi Q96GD4
STRINGi 9606.ENSP00000313950

Chemistry databases

BindingDBi Q96GD4

Miscellaneous databases

RNActi Q96GD4, protein

Structurei

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

3D structure databases

SMRi Q96GD4
ModBasei Search...
PDBe-KBi Search...

Family & Domainsi

Domains and Repeats

Feature key Position(s) DescriptionActions Graphical view Length
Domaini 77 – 327 Protein kinasePROSITE-ProRule annotationAdd BLAST 251

Region

Feature key Position(s) DescriptionActions Graphical view Length
Regioni 1 – 22 DisorderedSequence analysisAdd BLAST 22

Sequence similaritiesi

Phylogenomic databases

eggNOGi KOG0580, Eukaryota
GeneTreei ENSGT00940000158980
InParanoidi Q96GD4
OMAi WPYGRQM
OrthoDBi 954262at2759
PhylomeDBi Q96GD4
TreeFami TF351439

Family and domain databases

InterProi View protein in InterPro
IPR030616, Aur
IPR028772, AURKB
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PANTHERi PTHR24350, PTHR24350, 1 hit
PTHR24350:SF4, PTHR24350:SF4, 1 hit
Pfami View protein in Pfam
PF00069, Pkinase, 1 hit
SMARTi View protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMi SSF56112, SSF56112, 1 hit
PROSITEi View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

10         20         30         40         50
MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT
        60         70         80         90        100
AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH
       110        120        130        140        150
FIVALKVLFK SQIEKEGVEH QLRREIEIQA HLHHPNILRL YNYFYDRRRI
       160        170        180        190        200
YLILEYAPRG ELYKELQKSC TFDEQRTATI MEELADALMY CHGKKVIHRD
       210        220        230        240        250
IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL PPEMIEGRMH
       260        270        280        290        300
NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPMGA
       310        320        330        340
QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA
Length:344
Mass (Da):39,311
Last modified:January 11, 2011 - v3
Checksum:iA5ED13EF5A1FAFBF
GO
Isoform 2 (identifier: Q96GD4-2) [UniParc]FASTAAdd to basket

Also known as: aurkb-sv1

The sequence of this isoform differs from the canonical sequence as follows:
     86-134: GKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH → ALLCLWPEASSVSSPSH

Show »

Length:312
Mass (Da):35,302
Checksum:i9499DAE479793112
GO
Isoform 3 (identifier: Q96GD4-3) [UniParc]FASTAAdd to basket

Also known as: aurkb-sv2

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: T → TR
     133-141: HHPNILRLY → QSWRSWQML
     142-344: Missing.

Note: Not expressed in normal liver, high expression in metastatic liver.Curated

Show »

Length:142
Mass (Da):16,211
Checksum:iD8AB62DA2CCFA385
GO
Isoform 4 (identifier: Q96GD4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »

Length:303
Mass (Da):34,760
Checksum:i301BAFF2494B3650
GO
Isoform 5 (identifier: Q96GD4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: T → TR

Show »

Length:345
Mass (Da):39,467
Checksum:iACB05C191F35F38C
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket

Entry Entry name Protein names Gene names Length Annotation
J3KTD6 J3KTD6_HUMAN
Aurora kinase
AURKB
 228 Annotation score:
J3QLN8 J3QLN8_HUMAN
Aurora kinase
AURKB
 230 Annotation score:
J3QR41 J3QR41_HUMAN
Aurora kinase
AURKB
 172 Annotation score:
J3KT86 J3KT86_HUMAN
Aurora kinase
AURKB
 242 Annotation score:
J3KRJ2 J3KRJ2_HUMAN
Aurora kinase
AURKB
 69 Annotation score:
J3KRF8 J3KRF8_HUMAN
Aurora kinase
AURKB
 123 Annotation score:

Sequence cautioni

The sequence AAH13300 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key Position(s) DescriptionActions Graphical view Length
Sequence conflicti 14 – 15 RQ → DK in AAC98891 (Ref. 5) Curated 2
Sequence conflicti 161 E → M in AAB65786 (PubMed:11471245).Curated 1
Sequence conflicti 161 E → M in AAC98891 (Ref. 5) Curated 1
Sequence conflicti 167 – 169 QKS → HKT in AAB65786 (PubMed:11471245).Curated 3
Sequence conflicti 179 T → TVRR in AAB65786 (PubMed:11471245).Curated 1
Sequence conflicti 180 I → VRAV in AAC98891 (Ref. 5) Curated 1
Sequence conflicti 226 P → T in BAA82709 (PubMed:9858806).Curated 1
Sequence conflicti 249 – 250 MH → ID in BAA82709 (PubMed:9858806).Curated 2
Sequence conflicti 271 Missing in BAA82709 (PubMed:9858806).Curated 1

Natural variant

Feature key Position(s) DescriptionActions Graphical view Length
Natural variantiVAR_040383 52 A → V1 PublicationCorresponds to variant dbSNP:rs55878091Ensembl. 1
Natural variantiVAR_027970 100 H → Q. Corresponds to variant dbSNP:rs3027254Ensembl. 1
Natural variantiVAR_040384 179 T → M1 PublicationCorresponds to variant dbSNP:rs55871613Ensembl. 1
Natural variantiVAR_027971 298 M → T8 PublicationsCorresponds to variant dbSNP:rs1059476Ensembl. 1

Alternative sequence

Feature key Position(s) DescriptionActions Graphical view Length
Alternative sequenceiVSP_047103 1 – 41 Missing in isoform 4. 1 PublicationAdd BLAST 41
Alternative sequenceiVSP_044384 69 T → TR in isoform 3 and isoform 5. 2 Publications 1
Alternative sequenceiVSP_044385 86 – 134 GKFGN…AHLHH → ALLCLWPEASSVSSPSH in isoform 2. 1 PublicationAdd BLAST 49
Alternative sequenceiVSP_044386 133 – 141 HHPNILRLY → QSWRSWQML in isoform 3. 1 Publication 9
Alternative sequenceiVSP_044387 142 – 344 Missing in isoform 3. 1 PublicationAdd BLAST 203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi		 AF008552 mRNA Translation: AAC12709.1
AB011450 mRNA Translation: BAA32136.1
AB011446 mRNA Translation: BAA82709.1
AF004022 mRNA Translation: AAB65786.1
AF015254 mRNA Translation: AAC98891.1
AB519677 mRNA Translation: BAI23190.1
AB519678 mRNA Translation: BAI23191.1
AB519679 mRNA Translation: BAI23192.1
BT019534 mRNA Translation: AAV38341.1
AK297976 mRNA Translation: BAG60286.1
AC135178 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90075.1
CH471108 Genomic DNA Translation: EAW90077.1
CH471108 Genomic DNA Translation: EAW90078.1
BC000442 mRNA Translation: AAH00442.3
BC009751 mRNA Translation: AAH09751.1
BC013300 mRNA Translation: AAH13300.2 Different initiation.
BC080581 mRNA Translation: AAH80581.1
CCDSi CCDS11134.1 [Q96GD4-1]
CCDS58514.1 [Q96GD4-4]
CCDS67162.1 [Q96GD4-5]
CCDS82065.1 [Q96GD4-2]
RefSeqi NP_001243763.1, NM_001256834.2 [Q96GD4-4]
NP_001271455.1, NM_001284526.1 [Q96GD4-5]
NP_001300879.1, NM_001313950.1 [Q96GD4-1]
NP_001300880.1, NM_001313951.1 [Q96GD4-4]
NP_001300881.1, NM_001313952.1
NP_001300882.1, NM_001313953.1 [Q96GD4-2]
NP_001300883.1, NM_001313954.1
NP_001300884.1, NM_001313955.1
NP_004208.2, NM_004217.3 [Q96GD4-1]
XP_011522372.1, XM_011524070.2
XP_011522374.1, XM_011524072.2 [Q96GD4-4]
XP_016880796.1, XM_017025307.1 [Q96GD4-4]

Genome annotation databases

Ensembli ENST00000316199; ENSP00000313950; ENSG00000178999 [Q96GD4-5]
ENST00000534871; ENSP00000443869; ENSG00000178999 [Q96GD4-4]
ENST00000578549; ENSP00000462207; ENSG00000178999 [Q96GD4-2]
ENST00000585124; ENSP00000463999; ENSG00000178999 [Q96GD4-1]
GeneIDi 9212
KEGGi hsa:9212
UCSCi uc002gkm.5, human [Q96GD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

  • 100% Identity

  • 90% Identity

  • 50% Identity

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi		 AF008552 mRNA Translation: AAC12709.1
AB011450 mRNA Translation: BAA32136.1
AB011446 mRNA Translation: BAA82709.1
AF004022 mRNA Translation: AAB65786.1
AF015254 mRNA Translation: AAC98891.1
AB519677 mRNA Translation: BAI23190.1
AB519678 mRNA Translation: BAI23191.1
AB519679 mRNA Translation: BAI23192.1
BT019534 mRNA Translation: AAV38341.1
AK297976 mRNA Translation: BAG60286.1
AC135178 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90075.1
CH471108 Genomic DNA Translation: EAW90077.1
CH471108 Genomic DNA Translation: EAW90078.1
BC000442 mRNA Translation: AAH00442.3
BC009751 mRNA Translation: AAH09751.1
BC013300 mRNA Translation: AAH13300.2 Different initiation.
BC080581 mRNA Translation: AAH80581.1
CCDSi CCDS11134.1 [Q96GD4-1]
CCDS58514.1 [Q96GD4-4]
CCDS67162.1 [Q96GD4-5]
CCDS82065.1 [Q96GD4-2]
RefSeqi NP_001243763.1, NM_001256834.2 [Q96GD4-4]
NP_001271455.1, NM_001284526.1 [Q96GD4-5]
NP_001300879.1, NM_001313950.1 [Q96GD4-1]
NP_001300880.1, NM_001313951.1 [Q96GD4-4]
NP_001300881.1, NM_001313952.1
NP_001300882.1, NM_001313953.1 [Q96GD4-2]
NP_001300883.1, NM_001313954.1
NP_001300884.1, NM_001313955.1
NP_004208.2, NM_004217.3 [Q96GD4-1]
XP_011522372.1, XM_011524070.2
XP_011522374.1, XM_011524072.2 [Q96GD4-4]
XP_016880796.1, XM_017025307.1 [Q96GD4-4]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji		 PDB entry Method Resolution (Å) Chain Positions PDBsum
4AF3 X-ray 2.75 A 55-344 [»]
SMRi Q96GD4
ModBasei Search...
PDBe-KBi Search...

Protein-protein interaction databases

BioGRIDi 114646, 600 interactors
ComplexPortali CPX-116, Chromosomal passenger complex
CORUMi Q96GD4
DIPi DIP-34530N
ELMi Q96GD4
IntActi Q96GD4, 99 interactors
MINTi Q96GD4
STRINGi 9606.ENSP00000313950

Chemistry databases

BindingDBi Q96GD4
ChEMBLi CHEMBL2185
DrugBanki DB05169, AT9283
DB06486, Enzastaurin
DB12010, Fostamatinib
DB04703, Hesperidin
DB07340, Reversine
DrugCentrali Q96GD4
GuidetoPHARMACOLOGYi 1937

PTM databases

iPTMneti Q96GD4
MetOSitei Q96GD4
PhosphoSitePlusi Q96GD4
SwissPalmi Q96GD4

Genetic variation databases

BioMutai AURKB
DMDMi 317373473

Proteomic databases

CPTACi CPTAC-1219
CPTAC-1228
CPTAC-1340
EPDi Q96GD4
jPOSTi Q96GD4
MassIVEi Q96GD4
MaxQBi Q96GD4
PaxDbi Q96GD4
PeptideAtlasi Q96GD4
PRIDEi Q96GD4
ProteomicsDBi 4709
7611
76623 [Q96GD4-1]

Protocols and materials databases

Antibodypediai 3128, 1077 antibodies
DNASUi 9212

Genome annotation databases

Ensembli ENST00000316199; ENSP00000313950; ENSG00000178999 [Q96GD4-5]
ENST00000534871; ENSP00000443869; ENSG00000178999 [Q96GD4-4]
ENST00000578549; ENSP00000462207; ENSG00000178999 [Q96GD4-2]
ENST00000585124; ENSP00000463999; ENSG00000178999 [Q96GD4-1]
GeneIDi 9212
KEGGi hsa:9212
UCSCi uc002gkm.5, human [Q96GD4-1]

Organism-specific databases

CTDi 9212
DisGeNETi 9212
GeneCardsi AURKB
HGNCi HGNC:11390, AURKB
HPAi ENSG00000178999, Tissue enhanced (bone marrow, lymphoid tissue)
MIMi 604970, gene
neXtProti NX_Q96GD4
OpenTargetsi ENSG00000178999
PharmGKBi PA36199
VEuPathDBi HostDB:ENSG00000178999.12
GenAtlasi Search...

Phylogenomic databases

eggNOGi KOG0580, Eukaryota
GeneTreei ENSGT00940000158980
InParanoidi Q96GD4
OMAi WPYGRQM
OrthoDBi 954262at2759
PhylomeDBi Q96GD4
TreeFami TF351439

Enzyme and pathway databases

PathwayCommonsi Q96GD4
Reactomei R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-4615885, SUMOylation of DNA replication proteins
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-68877, Mitotic Prometaphase
R-HSA-9022692, Regulation of MECP2 expression and activity
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SignaLinki Q96GD4
SIGNORi Q96GD4

Miscellaneous databases

BioGRID-ORCSi 9212, 815 hits in 1042 CRISPR screens
GeneWikii Aurora_B_kinase
GenomeRNAii 9212
Pharosi Q96GD4, Tchem
PROi PR:Q96GD4
RNActi Q96GD4, protein
SOURCEi Search...

Gene expression databases

Bgeei ENSG00000178999, Expressed in ventricular zone and 155 other tissues
ExpressionAtlasi Q96GD4, baseline and differential
Genevisiblei Q96GD4, HS

Family and domain databases

InterProi View protein in InterPro
IPR030616, Aur
IPR028772, AURKB
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PANTHERi PTHR24350, PTHR24350, 1 hit
PTHR24350:SF4, PTHR24350:SF4, 1 hit
Pfami View protein in Pfam
PF00069, Pkinase, 1 hit
SMARTi View protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMi SSF56112, SSF56112, 1 hit
PROSITEi View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
MobiDBi Search...

Entry informationi

Entry namei AURKB_HUMAN
Accessioni Primary (citable) accession number: Q96GD4
Secondary accession number(s): B4DNM4 Q9UQ46
Entry historyi Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 11, 2011
Last modified: June 2, 2021
This is version 221 of the entry and version 3 of the sequence. See complete history.
Entry statusi Reviewed (UniProtKB/Swiss-Prot)
Annotation program Chordata Protein Annotation Program
Disclaimer Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index

  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

  3. Human entries with genetic variants
    List of human entries with genetic variants

  4. 从文献报告中挑选出
    的人类变异 从文献报告中挑选出的人类变异索引

  5. MIM 交叉引用
    UniProtKB/Swiss-Prot 中的在线人类孟德尔遗传 (MIM) 交叉引用

  6. PDB 交叉引用
    蛋白质数据库索引 (PDB) 交叉引用

  7. 相似性评论
    蛋白质结构域和家族的索引

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