【罂粟摘要】膝神经射频消融术与关节内富含血小板血浆治疗慢性膝骨关节炎的疗效比较：一项单盲随机临床试验
膝神经射频消融术与关节内富含血小板血浆治疗慢性膝骨关节炎的疗效比较：一项单盲随机临床试验
贵州医科大学 高鸿教授课题组
翻译：任文鑫 编辑：佟睿 审校：曹莹
随着老龄化人口的增加，慢性膝关节骨性关节炎是一个常见的问题。脉冲射频和关节内富含血小板血浆注射是缓解这类患者疼痛的有效方法。
本研究的主要目的是比较视觉模拟量表（visualanalog scale）评估的两种疼痛缓解方式。第二个目标是Lequesne对膝关节骨关节炎严重程度指数的改变。
单盲随机干预临床试验。
大学医院。
将200例慢性膝骨关节炎患者随机分为2组。PRF组给予脉冲射频治疗，PRP组给予关节内富含血小板血浆治疗。分别于干预前、干预后1周（仅视觉模拟评分）、干预后3、6、12个月进行视觉模拟评分和骨关节炎严重程度指数的评估。
6个月和12个月时，PRF组的视觉模拟评分明显低于PRP组，P值分别为0.01和0.04。关于骨关节炎严重程度的干预后指数，在3个月、6个月和12个月的随访中，PRF组显著低于PRP组，P值为0.001。
数据收集中不包括物理和镇痛治疗，也没有对照组。
膝神经脉冲射频治疗慢性膝关节骨性关节炎，在持续缓解疼痛和降低严重程度方面优于膝关节内富含血小板血浆注射。
Abdelraheem Elawamy, Emad Zarief Kamel, Safaa A. Mahran, Hebatallah Abdellatif and Manal Hassanien.Efficacy of Genicular Nerve Radiofrequency Ablation Versus Intra-Articular Platelet Rich Plasma in Chronic Knee Osteoarthritis: A SingleBlind Randomized Clinical Trial.Pain Physician 2021;24:127-134 · ISSN 1533-3159.
Efficacy of Genicular Nerve Radiofrequency Ablation Versus Intra-Articular Platelet Rich Plasma in Chronic Knee Osteoarthritis: A SingleBlind Randomized Clinical Trial
Background: Chronic knee osteoarthritis is a common problem with increasing of the aging population. Pulsed radiofrequency and intraarticular platelet rich plasma injection are well evidenced beneficial modalities for pain alleviation in such groups of patients.
Objective: The primary goal in this study was to compare the 2 modalities regarding pain alleviation evaluated by visual analog scale. The secondary goal focused upon the change of the Index of Severity for Osteoarthritis of the Knee by Lequesne.
Study Design: Single-blind randomized interventional clinical trial.
Setting: University hospitals.
Methods: Two hundred patients with chronic knee osteoarthritis were equally and randomly distributed into 2 groups. Group PRF received pulsed radiofrequency, whereas the group PRP received intraarticular platelet-rich plasma. The visual analog scale and index of severity of osteoarthritis were evaluated before intervention, after one week (for visual analog scale only), then after 3, 6, and 12 months.
Results: Visual analog scale was significantly lower in the PRF group compared to the PRP group at 6 and 12 months with P-values of 0.01 and 0.04, respectively. Regarding to the postinterventional index of severity of osteoarthritis, it was significantly lower in the PRF group than the PRP group with P-values of 0.001 at 3, 6, and 12 months follow-up.
Limitations: Physical and analgesic therapy were not included in data collection, and there was no control group.
Conclusion: Pulsed radiofrequency of the genicular nerves can be considered superior to knee intraarticular platelet-rich plasma injection for sustained pain relief and the lower severity index in patients with chronic knee osteoarthritis.