JGG：微生物组学专刊(赵方庆、白洋、张志刚、王军、郑钜圣、魏泓、沈伟、刘永鑫等）

Journal of Genetics and Genomics 微生物组学专刊已经在线发表，欢迎大家下载预览。下载网址：https://www.sciencedirect.com/journal/journal-of-genetics-and-genomics/vol/48/issue/9本期封面

On the Cover: In the natural ecosystem, microorganisms mainly perform their functions and driving roles in the form of microbial communities, which maintain the structure, function and dynamic balance of the ecosystem at all levels. Microbiome research has become the high ground of global scientific and technological competition in human disease prevention and treatment, industrial and agricultural production, and environmental management, etc. With recent progress of microbiome studies, we have an initial knowledge of the composition of microbial communities in various ecosystems, but we are still far from a comprehensive understanding of their community dynamics and functions. The studies in this special issue will unveil microbial composition in diverse hosts and advance our knowledge of the relationship between the microbiome and host’s health, lifestyle, and physiology. The cover image illustrates the host-associated microbial communities directly impact our life everywhere.Mini-ReviewMicrobiota-gut-brain axis in autism spectrum disorderYou Yu, Fangqing Zhaohttps://doi.org/10.1016/j.jgg.2021.07.001

中国科学院北京生命科学研究院赵方庆研究员团队发表综述，从神经、免疫及代谢等方面介绍了肠道菌群在自闭症谱系障碍中调节神经发育的最新进展。Innate lymphoid cells and gastrointestinal diseaseZiyu Wang, Jun Wanghttps://doi.org/10.1016/j.jgg.2021.08.004

中国科学院微生物研究所王军研究员团队发表综述，总结了固有淋巴细胞与多种胃肠道疾病间的关联，展望了固有淋巴细胞在免疫治疗方面可能的应用前景。Original ResearchAltered gut microbiome in FUT2 loss-of-function mutants in support of personalized medicine for inflammatory bowel diseasesSijing Cheng, Jun Hu, Xianrui Wu, Ji-an Pan, Na Jiao, Yichen Li,Yibo Huang, Xutao Lin, Yifeng Zou, Yuan Chen, Lixin Zhu, Min Zhi, Ping Lanhttps://doi.org/10.1016/j.jgg.2021.08.003

中山大学附属第六医院胃肠病学研究所兰平教授团队和郅敏主任团队合作发表研究论文，报道了FUT2功能缺失突变可改变肠道菌群，进而引发炎症性肠病，同时对其相关机制进行探讨。Characteristic dysbiosis in gout and the impact of a uric acid-lowering treatment, febuxostat on the gut microbiotaSuxian Lin, Tao Zhang, Lingxiao Zhu, Kun Pang, Saisai Lu, Xin Liao, Senhong Ying, Lixia Zhu, Xin Xu, Jinyu Wu, Xiaobing Wanghttps://doi.org/10.1016/j.jgg.2021.06.009

温州医科大学附属第一医院王晓冰副主任医师团队发表研究论文，报道了降尿酸的非布司他类药物治疗痛风前后肠道微生态变化，确定相应微生物区系功能特征，为揭示痛风发病机制和治疗方案提供新思路。Gut microbiota,inflammation, and molecular signatures of host response to infectionWanglong Gou,Yuanqing Fu, Liang Yue, Geng-Dong Chen, Xue Cai, Menglei Shuai, Fengzhe Xu, Xiao Yi, Hao Chen, Yi Zhu, Mian-Li Xiao, Zengliang Jiang, Zelei Miao, Congmei Xiao, Bo Shen, Xiaomai Wu, Haihong Zhao, Wenhua Ling, Jun Wang, Yu-Ming Chen,Tiannan Guo, Ju-Sheng Zhenghttps://doi.org/10.1016/j.jgg.2021.04.002

西湖大学郑钜圣教授团队、郭天南教授团队，中山大学陈裕明教授团队和中国科学院微生物研究所王军研究员团队合作发表研究论文，通过结合多维组学生物信息学分析，探索了肠道菌群、炎症因子以及COVID-19重症标记物间的关联，为研究肠道菌群与宿主免疫之间的相互作用，评估感染COVID-19后的重症风险提供新线索。Progressive deterioration of the upper respiratory tract and the gut microbiomes in children during the early infection stages of COVID-19Rong Xu, Pengcheng Liu, Tao Zhang, Qunfu Wu, Mei Zeng,Yingying Ma, Xia Jin, Jin Xu, Zhigang Zhang, Chiyu Zhanghttps://doi.org/10.1016/j.jgg.2021.05.004

复旦大学附属上海市公共卫生临床中心张驰宇教授团队、云南大学张志刚研究员团队和复旦大学附属儿科医院徐锦研究员团队合作发表研究论文，报道了COVID-19感染可以引起儿童上呼吸道和肠道菌群的持续扰动和失衡。Carrageenan oligosaccharides and associated carrageenan-degrading bacteria induce intestinal inflammation in germ-free miceYeshi Yin, Miaomiao Li, Weizhong Gu, Benhua Zeng, Wei Liu,Liying Zhu, XiongePi, Donald A. Primerano, Hongwei D. Yu, Hong Wei, Guangli Yu, Xin Wanghttps://doi.org/10.1016/j.jgg.2021.08.001

浙江省农科院省部共建农产品质量安全危害因子与风险防控国家重点实验室王欣研究员团队、中国海洋大学于广利教授团队和中国人民解放军陆军军医大学魏泓教授团队合作发表研究论文，报道了肠道分离获得的卡拉胶降解菌可以加重诱发直肠炎症。Comparative study of gut microbiota from captive and confiscated-rescued wild pangolinsChunbing Liu, Jingyang Hu, Yajiang Wu, David M. Irwin, Wu Chen,Zhigang Zhang, Li Yuhttps://doi.org/10.1016/j.jgg.2021.07.009

云南大学省部共建云南生物资源保护与利用国家重点实验室于黎研究员团队、张志刚研究员团队和广州动物园（广州野生动物研究中心）陈武高级兽医师团队合作发表研究论文，比较了穿山甲肠道微生物在人工圈养和野生环境下的微生物组成与功能变化。该研究为优化圈养穿山甲的饮食结构、抗生素使用，探讨潜在患病机制提供重要理论依据，对野生穿山甲的保护具有重要指导意义。The rice histone methylation regulates hub species of the root microbiotaZhiyao Lv, Rui Dai, Haoran Xu, Yongxin Liu, Bo Bai, Ying Meng,Haiyan Li, Xiaofeng Cao, Yang Bai, Xianwei Song, Jingying Zhanghttps://doi.org/10.1016/j.jgg.2021.06.005

中国科学院遗传与发育生物学研究所白洋研究员团队和曹晓风研究员团队合作发表研究论文，报道了组蛋白甲基化修饰对水稻根系微生物群落组装及核心菌群的调控作用，为植物表观遗传调控与根系微生物群之间的联系提供新思路。ResourceTaxonKit: A practical and efficient NCBI taxonomy toolkitWei Shen, Hong Renhttps://doi.org/10.1016/j.jgg.2021.03.006

重庆医科大学病毒性肝炎研究所任红教授和沈伟博士合作发表研究论文，报道了一款功能丰富且计算性能高效的NCBI分类学数据操作工具TaxonKit。该工具由7个子命令组成，支持多操作系统，功能相对独立，且组合后可实现复杂功能，同时易于集成到生物信息分析流程中。MethodA powerful adaptive microbiome-based association test for microbial association signals with diverse sparsity levelsHan Sun, Xiaoyun Huang, Lingling Fu, Ban Huo, Tingting He, Xingpeng Jianghttps://doi.org/10.1016/j.jgg.2021.08.002

华中师范大学计算机学院蒋兴鹏教授团队发表研究论文，针对不同稀疏水平的微生物关联信号，提出一种微生物组关联检验新方法，用于检验微生物组与疾病表型之间关联的统计显著性。Letter to the EditorAn efficient metatranscriptomic approach for capturing RNA virome and its application to SARS-CoV-2Yao Meng, Liwen Xiao, Wenbing Chen, Fangqing Zhao, Xiang Zhaohttps://doi.org/10.1016/j.jgg.2021.08.005

中国科学院北京生命科学研究院赵方庆研究员团队和西安交通大学赵翔助理研究员团队合作发表研究论文。该研究开发了一种快速、价廉，对RNA病毒更敏感的宏转录组测序建库方法，适用于临床上对SARS-CoV-2共感染的研究，可用于帮助发现和鉴定未知病原。EVenn: Easy to create repeatable and editable Venn diagrams and Venn networks onlineTong Chen, Haiyan Zhang, Yu Liu, Yong-Xin Liu, Luqi Huanghttps://doi.org/10.1016/j.jgg.2021.07.007

中国中医科学院黄璐琦院士团队和中国科学院遗传与发育生物学研究所刘永鑫高级工程师合作发表研究论文，介绍了一款用于数据交互性探索和可视化的一站式Venn图和Venn网络在线绘制平台。