Nature子刊：膳食纤维如何精准调控肠道微生物组 | 热心肠日报
Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
菌群导向性纤维激活肠道远端内的目标菌及相关代谢改变
10.1038/s41467-020-19585-0
11-13, Article
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Beneficial modulation of the gut microbiome has high-impact implications not only in humans, but also in livestock that sustain our current societal needs. In this context, we have tailored an acetylated galactoglucomannan (AcGGM) fibre to match unique enzymatic capabilities of Roseburia and Faecalibacterium species, both renowned butyrate-producing gut commensals. Here, we test the accuracy of AcGGM within the complex endogenous gut microbiome of pigs, wherein we resolve 355 metagenome-assembled genomes together with quantitative metaproteomes. In AcGGM-fed pigs, both target populations differentially express AcGGM-specific polysaccharide utilization loci, including novel, mannan-specific esterases that are critical to its deconstruction. However, AcGGM-inclusion also manifests a “butterfly effect”, whereby numerous metabolic changes and interdependent cross-feeding pathways occur in neighboring non-mannanolytic populations that produce short-chain fatty acids. Our findings show how intricate structural features and acetylation patterns of dietary fibre can be customized to specific bacterial populations, with potential to create greater modulatory effects at large.
First Authors:
Leszek Michalak
Correspondence Authors:
John Christian Gaby,Phillip B Pope,Bjørge Westereng
All Authors:
Leszek Michalak,John Christian Gaby,Leidy Lagos,Sabina Leanti La Rosa,Torgeir R Hvidsten,Catherine Tétard-Jones,William G T Willats,Nicolas Terrapon,Vincent Lombard,Bernard Henrissat,Johannes Dröge,Magnus Øverlie Arntzen,Live Heldal Hagen,Margareth Øverland,Phillip B Pope,Bjørge Westereng