Horner– Wadsworth–Emmons反应Masamune–Roush改进法

Applicable to base-sensitive aldehydes and phosphonates for the reaction to prepare olefins. 􀁄-Keto or 􀁄-alkoxycarbonyl

phosphonate required.

本反应适用于对碱不稳定的醛和膦酸酯进行 Horner–Wadsworth–Emmons反应制备烯烃。膦酸酯必须是α-酮基或α-烷氧羰基膦酸酯。

反应机理

最后生成热力学稳定的P=O键是反应进行的驱动力。

反应实例

参考文献

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编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Masamune–Roush conditions for the Horner–Emmons reaction，page 382-383.