Neurology病例：1型神经纤维瘤病的T2高信号

一名4岁男孩患有1型神经纤维瘤（NF1）、无症状的视神经胶质瘤和右侧基底节T2高强度病变（图A和图B），在一年的时间内出现左偏瘫伴反射亢进。神经影像学显示在他先前确定的T2高强度区域有一个类似囊肿的肿块（图，c和d）。虽然在没有组织诊断的情况下很难区分T2高信号和低级别胶质瘤，即使采用先进的成像方法，T2高信号通常随着年龄的增长而消失，并且不会变成囊性，伴有相关的占位效应。再加上新的神经症状的发展，这些核磁共振特征是令人担忧的肿瘤患者的NF1。

图：从2003年起，T2高信号在一个神经纤维瘤病1型儿童脑磁共振成像（MRI）被发现，提示在右基底神经节T2高信号，在神经纤维瘤病1型儿童经常被观察到。

英文原文：

A 4-year-old boy with neurofibromatosis type 1 (NF1), anasymptomatic optic glioma, and a right basal ganglia T2-hyperintense lesion (figure, A andB) developed a lefthemiparesis with hyperreflexia over the course of a year. Neuroimaging revealeda cyst-like mass in the region of his previously identified T2 hyperintensity (figure, C andD). While it is oftendifficult to distinguish T2 hyperintensities from low-grade glioma withouttissue diagnosis,1 even with advanced imaging methods,2 T2 hyperintensities typically disappear with age and do notbecome cystic with associated mass effect. Coupled with the development of newneurologic signs, these MRI features are worrisome for neoplasm in a patientwith NF1.

Figure T2 hyperintensities in a child with neurofibromatosistype 1 Brain MRI from 2003 revealed a T2 hyperintensity in the right basalganglia, frequently observed in children with neurofibromatosis type 1.